在肥胖患者中对中度热量限制和甲福林治疗的多方向评估
A Kanikowska1, D Kanikowska2, E Swora-Cwynar1
1Department of Internal Diseases, Metabolism and Nutrition, Poznan University of Medical Science, Poznan, Poland.
概括
适度的热量限制 (CR) 与甲福明改善了成年人肥胖标志物和胰岛素敏感性. 单独CR和CR与甲福林减少体重,改善心血管健康,减少炎症,对脏或胰腺功能没有不良影响.
科学领域:
- 内分泌学 在内分泌学.
- 代谢疾病 代谢疾病
- 营养科学 营养科学
背景情况:
- 肥胖是一个重大的全球健康挑战,往往需要多方面的治疗方法.
- 目前的肥胖治疗对患者来说可能是沉重的,需要探索有效和耐受的干预措施.
- 低血糖药物梅特福明 (Metformin) 越来越多地被研究其超出糖尿病管理范围的潜在作用.
研究的目的:
- 评估中度热量限制 (CR) 与肥胖患者的甲福明相结合的多方向效应.
- 为了在各种健康参数上比较单独中度CR与中度CR与甲福明的疗效.
- 评估对人类学,心血管,炎症和代谢标记以及器官功能的影响.
主要方法:
- 一个随机对照试验,涉及两组肥胖患者.
- 第1组:只有适度的热量限制 (CR) (n=21).
- 第二组:中度CR每天两次服用800毫克甲福林 (n=23).
- 监测包括治疗前后的人类测量,心血管,炎症,代谢和器官功能标志物.
主要成果:
- 这两组在人体测量指标 (体重,BMI,腰围) 和脂肪质量方面均显著改善.
- 两组人都表现出较高的缩血压,胰岛素敏感性和较低的炎症标志物.
- 甲福明组的尿酸和阿斯巴酸氨基转移酶 (AspAT) 活性下降;然而,甘油三酸仅在单独使用CR时才降低. 甲胺组在治疗后也有更高的C-反应蛋白 (CRP) 和HOMA-IR,但葡萄糖不耐受性减少更大.
- 在两组中都没有观察到脏或胰腺功能的显著变化.
结论:
- 八周的中度CR,有或没有甲福明,有效地改善了肥胖成年人的人类计量和代谢标志物.
- 这两种干预都导致肌肉质量减少,自由三铁素 (fT3),玛谷氨基转移酶 (GGT),以及促炎和心血管参数.
- 与CR结合的甲福明显著改善了胰岛素敏感性和降低了葡萄糖不耐受性,尽管一些组最初显示出更高的炎症标志物.
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