沙门氏菌与两个不同的传播载体相关的哈达突出显示了肠道疾病爆发调查的挑战
Joshua M Brandenburg1,2, Gregory Sean Stapleton1,2, Kelly E Kline3
1Division of Foodborne, Waterborne and Environmental Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Epidemiology and infection
|May 13, 2024
概括
2020-2021年两次沙门氏菌哈达感染爆发与后院家禽和土有关. 基因分析显示了密切的相关性,但传播源仍然不清楚,需要先进的调查方法.
科学领域:
- 食物传播疾病流行病学
- 微生物基因组学 微生物基因组学
- 公共卫生监督是对公共卫生的监督.
背景情况:
- 2020年发生了一次 *Salmonella* Hadar 感染的爆发,与后院家禽接触有关.
- 在2020-2021年晚些时候,同一个 *Salmonella* Hadar 菌株的随后爆发被确定,与地面火消费有关.
研究的目的:
- 为了研究沙门氏菌之间的遗传关系,哈达尔从两个不同的爆发中分离出来.
- 探索后院家禽和商业地面火来源之间的潜在联系和传播途径.
主要方法:
- 核心基因组多部位序列类型化 (cgMLST) 用于分析Hadar*Salmonella*分离物的遗传相关性.
- 进行了流行病学和追踪调查,以确定污染源.
主要成果:
- cgMLST分析显示,这两次疫情的分离物在遗传上是密切相关的 (0-16个等位基因的差异).
- 流行病学和追踪努力无法最终将后院家禽和地面火疫情联系起来.
结论:
- 先进的基因组方法,如泛基因组分析,可能需要阐明疫情之间的准确关系.
- 加强数据收集和进一步的研究对于了解菌的持久性和跨禽业传播至关重要.
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