压力和原发性甲状腺功能低下症的关联
Monika Singh1, Jagdish Narayan1, Ruchika Thakur1
1Department of Physiology, King George's Medical University, Lucknow, Uttar Pradesh, India.
Journal of family medicine and primary care
|May 13, 2024
概括
这项研究发现,与健康对照人群相比,甲状腺功能低下症患者的压力水平更高,心率变化更大. 这些发现突显了压力和原发性甲状腺功能低下症之间的重要联系,影响了心血管功能.
科学领域:
- 内分泌学 在内分泌学.
- 心血管生理学心血管生理学
- 心理神经免疫学 心理神经免疫学
背景情况:
- 甲状腺功能低下症涉及甲状腺激素的产生受损,影响心血管系统.
- 压力因素可能会破坏下丘脑-垂体-甲状腺 (HPT) 轴,影响生理和心理反应.
- 在压力期间甲状腺激素升高和TSH降低可以加剧自身免疫性甲状腺疾病.
研究的目的:
- 为了研究压力和原发性甲状腺功能低下症之间的关联.
- 用心率变化 (HRV) 来分析甲状腺功能下降患者的心血管自主功能.
主要方法:
- 与77名新诊断的甲状腺功能低下患者 (TSH>5.0mIU/L) 和77名健康对照 (TSH0.5-5.0mIU/L) 进行了比较.
- 测量生命体征并进行心血管检查.
- 使用专用软件分析心率变化 (HRV).
主要成果:
- 甲状腺功能低下患者的平均平均水平显著高于平均平均水平. RR和PSS得分,表明心率变化和感知压力的增加.
- 低RM SSD,pRR50和HF值在甲状腺功能下降患者表明受损的副交感活动.
- 在甲状腺功能低下患者中,较高的LF/HF比率表明了交感主导.
- TSH水平与LF/HF比率和感知应激量表 (PSS) 评分有很强的相关性.
结论:
- 甲状腺功能低下的患者表现出心率波动的显著变化,表明自主功能障碍.
- 在患有原发性甲状腺功能低下症的个体中,压力水平升高很普遍.
- 该研究确立了TSH水平,压力和低甲状腺症中心血管自主调节之间的显著相关性.
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