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豆摄入量可能会防止冠状动脉疾病:13种饮食特征的门德尔随机化

Joshua K Park^1,2,3, Ben Omega Petrazzini^1,2, Shantanu Bafna^1,2

¹Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.

|May 13, 2024

概括

消费肉可能会因果性地降低冠状动脉疾病 (CAD) 的风险. 这种效应可能是由酸盐,肠道微生物群衍生代谢物,突出肠道菌群在心血管健康中的作用.

科学领域:

营养流行病学营养流行病学
心血管遗传学心血管遗传学
代谢学代谢学代谢学

背景情况:

饮食是冠状动脉疾病 (CAD) 的重要可改变的风险因素.
特定饮食习惯对CAD风险的确切因果影响需要进一步阐明.
门德尔随机化 (MR) 提供了一种强大的方法来研究饮食-CAD因果关系,使用大规模生物库数据.

研究的目的:

系统地评估13个常见的饮食特征对CAD风险的因果关系,使用两个样本的MR框架.
识别潜在的血代谢物,调解饮食和CAD之间的关系,特别是在怀疑因果关系的特征.

主要方法:

使用来自英国生物银行 (多达420,531个人) 和欧洲血统的CARDIoGRAMplusC4D (多达184,305个人) 的遗传和饮食数据进行了两种样本的MR分析.
主要分析采用固定效应逆变量加权回归.
敏感性分析包括加权中位数估计,MR-Egger回归和MR-Pleiotropy残余和异常值 (MR-PRESSO),以确保稳定性.

主要成果:

与肉摄入相关的遗传变异与CAD风险有显著的反向关联 (OR: 0.74; 95% CI: 0.65-0.84; P = 5.385 × 10-4).
敏感性分析,包括加权中位数估计,证实了肉与CAD的保护性关联.
血乙酸盐水平升高被确定为这种关联的潜在媒介 (OR:0.03;95%CI:0.01-0.12;P = 1.15 × 10-4).

结论:

作为一种复合食品的米斯利,在降低冠状动脉疾病风险方面发挥了潜在的因果作用.
循环中的乙酸,一种由肠道微生物群产生的短链脂肪酸,可能会调解粘液的心脏保护作用.
这些发现强调了肠道微生物群在心血管健康中的重要性,并可以为未来的CAD预防饮食干预试验提供信息.

关键词:

卡迪奥格拉姆加C4D 英国生物银行乙酸乙烯的使用方法心血管疾病心血管疾病遗传流行病学遗传流行病学代谢生物组的代谢生物组

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