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慢性炎症性去髓化的多基基隆性神经病与神经omyelitis optica光谱障碍相关:一个罕见的病例报告

Baarid Luqman Hamidi^1,2,3, Diah Kurnia Mirawati^1,2, Rachmi Fauziah Rahayu^4,2

¹Department of Neurology, Faculty of Medicine, Universitas Sebelas Maret Ir. Sutami Street No. 36, Kentingan, Jebres, Surakarta, Central Java 57126, Indonesia.

Preventive medicine reports

|May 13, 2024

概括

这份报告详细介绍了一种罕见的慢性炎症性脱叶林性多基基隆性神经病 (CIDP) 病例,与神经omyelitis optica光谱障碍 (NMOSD) 同时发生. 用皮质类固醇和免疫抑制剂治疗在这个独特的患者中显示出积极的临床结果.

科学领域:

神经免疫学神经免疫学
神经学神经学
罕见疾病罕见疾病

背景情况:

慢性炎症性脱线性多基基隆性神经病变 (CIDP) 影响了周围神经系统的髓层.
神经omyelitis光学谱系障碍 (NMOSD) 是一种针对天体细胞的自身免疫性疾病,通常与抗水素-4抗体 (AQP4-Ab) 相关.
CIDP和NMOSD同时发生的情况非常罕见.

研究的目的:

报告一个独特的病例,患者呈现CIDP和NMOSD.
描述这种罕见的综合疾病的临床表现,诊断结果和治疗方法.
为了突出结合免疫抑制疗法的治疗反应.

主要方法:

一个49岁的女性患有神经症状的病例报告.
诊断工作包括MRI,视觉和体感官唤起潜能,以及对AQP4-Ab.Ab的血清学测试.
进行了电肌图,以评估外围神经的参与.
治疗包括静脉注射的皮质类固醇,甲醇和阿扎西奥普林.

主要成果:

该患者的症状和诊断结果与CIDP和NMOSD (AQP4-Ab阳性) 一致.
核磁共振显示道森的手指和新的病变,表明NMOSD.
唤起的潜能显示了中央和外围的脱髓化.
患者在接受皮质类固醇和免疫抑制剂治疗后经历了临床改善.

结论:

同时发生CIDP和NMOSD是一种罕见的临床实体.
皮质类固醇和免疫抑制剂的组合证明在管理这个患者的病情方面是有效的.
需要进一步研究中枢和外围脱结合的潜在免疫机制和病理学.

关键词:

这是自身免疫性疾病.在CIDP中,我们可以看到CIDP.有多个脱髓化病变.这是NMOSD的NMOSD.罕见疾病是一种罕见的疾病.

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