使用计算模拟增强机械循环支持装置的植入
Gabriela Lopez-Santana1,2, Alessandro De Rosis1, Stuart Grant3,4
1School of Engineering, The University of Manchester, Manchester, United Kingdom.
Frontiers in bioengineering and biotechnology
|May 13, 2024
概括
在左心室辅助装置 (LVAD) 植入过程中优化外流移植位置可以减少大动脉并发症. 特定的角度和距离最大限度地减少对大动脉根的有害血液动力力,改善患者的治疗结果.
科学领域:
- 生物医学工程 生物医学工程
- 心血管研究研究心血管研究
- 计算流体动力学的流体动力学.
背景情况:
- 末期心力衰竭通常需要使用左心室辅助器件 (LVAD) 进行机械循环支持.
- 植入LVAD带有风险,包括大动脉反和血栓形成.
- 优化手术技术可以减轻这些并发症.
研究的目的:
- 评估优化LVAD外流移植 (OG) 植入技术是否可以最大限度地降低大动脉并发症的风险.
- 为了评估OG解剖的不同几何参数对大动脉流动模式的影响.
主要方法:
- 计算流体动力学 (CFD) 用于模拟大动脉流动模式.
- 创建了一个3D主动脉模型,从心室 - 动脉结点,枢纽位置和角度变化的OG距离.
- 作为入口边界,使用了LVAD连续流和原生心脏周期.
主要成果:
- 特定的OG定位显著影响血液动力学参数,如壁切应力 (WSS).
- 在45°±10°的角度将OG固定在冠状侧,距离AVJ55毫米,大动脉根WSS减少了约50%.
- 在CFD分析中,量化了OG位置对速度,压力,旋转和动动能的影响.
结论:
- 出流移植的位置是影响LVAD患者血液动力学模式的关键因素.
- CFD建模为优化OG定位提供了有价值的工具,以减少LVAD植入后的心血管并发症.
- 这种方法有可能改善机械循环支持患者的长期结果.
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