动物繁殖中的介质干细胞:来源,用途和场景
Andrei Takeshita de Oliveira1, Antonio Rodrigues Ferreira Braga1, José Ricardo Fonseca Miranda1
1Undergraduate in Veterinary Medicine, Faculdade de Zootecnia e Engenharia de Alimentos (FZEA), Universidade de São Paulo (USP). Pirassununga, SP, Brazil.
Brazilian journal of veterinary medicine
|May 13, 2024
概括
中介细胞干细胞 (MSCs) 在改善卵巢功能方面表现有前途. 在小鼠和牛身上进行的研究表明,MSC可以提高卵细胞质量,胚胎生产和卵泡发育,帮助卵巢恢复.
科学领域:
- 生殖生物学 生殖生物学
- 干细胞疗法是一种干细胞疗法.
- 兽医医学 兽医医学 兽医医学
背景情况:
- 介质细胞干细胞 (MSCs) 在20世纪60年代被发现,以其再生特性和迁移到受伤组织的能力而闻名.
- 这些细胞分泌刺激组织修复和合成的因素,在各种医学领域提供治疗潜力.
- 之前的研究已经探索了MSCs用于改善卵巢功能,特别是在过早衰老和卵泡储备减少的情况下.
研究的目的:
- 评估介质干细胞 (MSC) 疗法在动物模型中改善卵巢功能方面的疗效.
- 研究MSCs对卵细胞质量,胚胎生产和卵巢组织发育的影响.
- 探索MSCs在生殖医学中的治疗应用的潜力.
主要方法:
- 在动物模型中对介质干细胞 (MSC) 应用现有研究的审查,包括动物和牛.
- 对卵巢功能和生殖参数的卵巢内MSC给药对卵巢功能影响的数据分析.
- 检查MSC治疗后的荷尔蒙,组织,细胞和代谢变化.
主要成果:
- 在过早衰老的小鼠中,MSC治疗对卵巢功能产生了积极的影响,增强了卵泡储备.
- 在雌性牛群中,实验性MSC疗法在体外改善了卵子质量,并在体内刺激了卵子生产.
- 卵巢内MSC的应用导致了体外胚胎生产的增加,包括早期和扩大的胚胎囊,以及更多的发育卵泡.
结论:
- 介质干细胞 (MSC) 疗法在不同物种和应用方法中显示出改善和恢复卵巢功能的巨大潜力.
- MSC治疗可以积极影响卵巢的荷尔蒙,组织,细胞和代谢水平,从而改善生殖结果.
- 对MSC的进一步研究为生殖医学和兽医科学中的治疗干预提供了有希望的途径.
相关概念视频
Mesenchymal Stem Cells
4.7K
Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
4.7K
Embryonic Stem Cells
3.5K
Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
ES cells are grown in a culture medium where they can divide indefinitely, creating ES cell lines. Under certain conditions, ES cells can differentiate, either spontaneously into a variety of...
ES cells are grown in a culture medium where they can divide indefinitely, creating ES cell lines. Under certain conditions, ES cells can differentiate, either spontaneously into a variety of...
3.5K
Stem Cell Therapy for Tissue Regeneration
4.0K
Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
4.0K
Stem Cell Culture
5.2K
Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
5.2K
Source And Potency Of Stem Cells
4.8K
Stem cells are undifferentiated cells with extensive self-renewal properties that help them maintain their population during the fetal and adult stages of life. They can specialize in all cell types of the human body. However, their differential potential may vary and can be classified into five types. Stem cells can be (1) Totipotent, (2) Pluripotent, (3) Multipotent, (4) Oligopotent, and (5) Unipotent. Each stem cell has a specific origin; the fertilized egg or zygote is a totipotent cell and...
4.8K
Reproductive Cloning
30.3K
Reproductive cloning is the process of producing a genetically identical copy—a clone—of an entire organism. While clones can be produced by splitting an early embryo—similar to what happens naturally with identical twins—cloning of adult animals is usually done by a process called somatic cell nuclear transfer (SCNT).
Somatic Cell Nuclear Transfer
In SCNT, an egg cell is taken from an animal and its nucleus is removed, creating an enucleated egg. Then a somatic...
Somatic Cell Nuclear Transfer
In SCNT, an egg cell is taken from an animal and its nucleus is removed, creating an enucleated egg. Then a somatic...
30.3K


