状细胞疾病的心血管后果
Salem Bahashwan1,2, Rahaf Mohammad Almuhanna3, Maryam Taher Al Hazza1
1Hematology Department, Faculty of Medicine, King Abdulaziz University, Jeddah, 21589, Saudi Arabia.
Journal of blood medicine
|May 13, 2024
概括
成年状细胞病 (SCD) 患者面临肺高血压 (PH) 和心律失常的风险,通常未被诊断. 慢性病显著增加了这些风险,强调了需要多学科护理的需要.
科学领域:
- 心脏病学 心脏病学
- 血液学 血液学 血液学
- 肺部病理学 肺部病理学
背景情况:
- 状细胞疾病 (SCD) 是一种遗传性血液疾病,具有潜在的严重心血管和呼吸道并发症.
- 这些并发症包括心律失常,肺高血压 (PH) 和心血管大病,影响成人患者的健康.
- 成年SCD患者面临PH和心律失常的风险,这些经常被诊断不足.
研究的目的:
- 研究患有状细胞疾病 (SCD) 的成年患者肺高血压 (PH) 和心律失常的患病率和危险因素.
主要方法:
- 从2009年到2021年,对517名成人SCD患者 (15岁以上) 的病历进行了回顾性分析.
- 对心声图和心电图进行了评估,使用ESC/ERS关于PH风险和心律失常检测的指南.
- 多变量逻辑回归确定了PH和心律失常的独立风险因素.
主要成果:
- 1.4%的患者有心律不整,3.7%有中度PH风险,3.3%有高PH风险.
- 慢性病 (CKD) 是一个显著的独立风险因素,增加PH的几率为26.4倍,心律失常的几率为15.36倍.
- 其他PH的关键风险因素包括肝硬化和先前存在的心脏病;心律失常与CKD和心脏病有关.
结论:
- 成年SCD患者有显著的PH和心律失常的风险,通常未被诊断.
- 慢性病,肝硬化和先前存在的心脏疾病是关键的危险因素.
- 建议多学科护理和前性研究用于早期检测和改善血红蛋白病患者的治疗结果.
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