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在检查点抑制剂类型和毒性方面具有不同的自身抗体配置文件

Hong Mu-Mosley1, Mitchell S von Itzstein1,2, Farjana Fattah1

  • 1Harold C. Simmons Comprehensive Cancer Center, UT Southwestern Medical Center, Dallas, TX, USA.

Oncoimmunology
|May 13, 2024
PubMed
概括

免疫检查点抑制剂 (ICI) 对自身抗体水平的影响不同. 含有ipilimumab的疗法增加了自身抗体,而nivolumab则降低了自身抗体,根据免疫相关的不良事件而有所变化.

关键词:
自动抗体是一种自身抗体.在 CTLA-4 中.在PD-1中使用PD-1.生物标志物 生物标志物免疫检查点抑制剂免疫检查点抑制剂与免疫相关的不良事件.免疫疗法 免疫疗法

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Idiosyncratic drug reactions represent abnormal chemical responses that vary significantly among individuals, ranging from extreme sensitivity to low doses to insensitivity to high doses. These reactions often occur due to the drug's covalent binding with serum proteins, forming a foreign hapten that triggers an immunotoxicological response. The variability in drug reactions has a strong pharmacogenetic foundation, with genetic differences crucial in how individuals metabolize drugs. For...
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