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二级医院中的21型三体瘤心脏并发症患者:一项描述性研究
Mohammed AlDar1, Ali Almaa2, Hussain Alturki2
1Pediatrics and Neonatology, Qatif Central Hospital, Qatif, SAU.
Cureus
|May 13, 2024
概括
在沙特阿拉伯的唐氏综合征 (DS) 患者中,先天性心脏缺陷 (CHD) 非常普遍,专利性动脉管是最常见的. 早期诊断和干预对于在DS患者中管理这些心脏异常至关重要.
科学领域:
- 心脏病学 心脏病学
- 遗传学 遗传学 是一个
- 儿科 儿科 儿科
背景情况:
- 唐氏综合症 (DS) 是由三形21引起的遗传性疾病,经常与先天性心脏缺陷 (CHD) 相关.
- 了解CHD在DS中的特定模式和流行率对于有效的临床管理和公共卫生策略至关重要.
研究的目的:
- 确定沙特阿拉伯唐氏综合征患者先天性心脏缺陷 (CHD) 的患病率和特征.
- 分析通过心声学和患者结局诊断的心脏异常.
主要方法:
- 来自卡提夫中央医院电子医疗记录的回顾性研究 (2012年3月-2022年3月).
- 纳入标准:被诊断为DS的患者 (ICD-10代码Q90.9).
- 数据收集包括心声回声学发现,手术干预和患者结果.
主要成果:
- 在研究的161名DS患者中,观察到心血管疾病的高患病率 (72.7%).
- 最常见的缺陷是动脉导管 (29.81%),心房隔膜缺陷 (27.95%),心房隔膜缺陷 (17.39%).
- 死亡率为32.3%,其中22.98%需要手术,60.87%幸存.
结论:
- 这项研究强调了沙特阿拉伯的DS患者中CHD的重大负担,具有特定的常见异常.
- 早期诊断,及时的手术干预和持续的随访对于改善结果至关重要.
- 结果可以为该地区的DS人口提供临床实践和公共卫生政策的信息.
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