肥胖对韩国老年人功能的影响:全国基于人口的队列研究
Jihyun Yang1, Hui Seung Lee2, Chi-Yeon Lim2
1Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
Kidney research and clinical practice
|May 13, 2024
概括
代谢综合征,而不是像BMI或腰围这样的肥胖指标,显著增加了老年人功能下降的风险. 代谢综合征成分的数量进一步提高了这种风险.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 老年病的医生 老年病的医生
- 代谢疾病 代谢疾病
背景情况:
- 肥胖是慢性病 (CKD) 的已知危险因素之一.
- 肥胖对老年人功能的具体影响尚不清楚.
- 这项研究调查了老年人肥胖和脏结果.
研究的目的:
- 检查肥胖指标与老年人功能下降之间的关联.
- 为了确定体质指数 (BMI),腰围 (WC) 或代谢综合征是否预测老年人群中的病进展.
主要方法:
- 对130,504名来自韩国国家医疗保险服务-高级队伍的参与者的分析.
- 使用BMI,性别特异性WC和代谢综合征标准进行肥胖评估.
- 功能下降定义为≥50%的EGFR下降或新发症末期病 (ESRD).
主要成果:
- 在559,531人年中,19.0%的人患有功能衰退.
- 无论是BMI还是WC都没有与功能下降有显著的关联.
- 代谢综合征的存在显著增加了功能下降的风险 (aHR,1.24;95% CI,1.13-1.36).
- 观察到剂量反应关系:当代谢综合征成分更多时,风险增加 (p趋势<0.001).
结论:
- 代谢综合征,而不是传统的肥胖指标,是韩国老年人功能下降的重要危险因素.
- 代谢综合征成分的数量与功能恶化的风险增加直接相关.
- 研究结果强调了代谢健康对老年人脏健康的重要性,而不是简单的肥胖指标.
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