循环的代谢学特征的比较分析确定了在不同的多压力军事训练演习中共享的代谢变化
Michael Daniels1,2, Lee M Margolis1, Jennifer C Rood3
1Military Nutrition Division, United States Army Research Institute of Environmental Medicine, Natick, Massachusetts, United States.
Physiological genomics
|May 13, 2024
概括
军事训练导致共同的代谢变化,特别是在脂质和氨基酸通路中. 这些变化可能表明在苛刻的运动过程中,压力,炎症和组织损伤的共同生理特征.
科学领域:
- 运动生理学 运动生理学
- 代谢学 代谢学 代谢学
- 军人卫生保健 军人卫生保健
背景情况:
- 军事训练给人带来独特的生理压力.
- 了解代谢反应是优化表现和健康的关键.
- 全球代谢概况提供了对这些反应的全面视图.
研究的目的:
- 在各种军事训练场景中识别共享的代谢特征变化.
- 描述与军事训练要求相关的共同代谢学特征.
- 探索代谢变化和生理压力标志物之间的相关性.
主要方法:
- 没有针对性的血液样本的全球代谢概况.
- 对三个不同的军事训练演习进行分析:生存训练 (ST),北极训练 (AT) 和控制能源赤字 (CED).
- 训练事件之前和之后的代谢物概况的比较.
主要成果:
- 在191 (ST),121 (AT) 和64 (CED) 代谢物中发现了显著的变化.
- 在所有三种训练类型中共享了87种代谢物变化,主要是脂质和氨基酸代谢.
- 观察到甲,脂肪酸和代谢的持续增加,以及二甲和尿素循环通路的减少.
结论:
- 不同的军事训练演习引起了代谢概况的重叠变化.
- 一个常见的代谢签名涉及脂质代谢,生成和氧化应激与军事训练有关.
- 这些代谢变化与炎症,组织损伤和抑制的合成代谢信号相关,反映出独特的生理需求.
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