在出现呼吸道症状的患者中,与身体后续相关的代谢模式验证了脱水患者的化概念
Annelie Barrueta Tenhunen1, Guillaume Butler-Laporte2,3, Satoshi Yoshiji3,4,5,6
1Anaesthesiology and Intensive Care Medicine, Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.
Physiological genomics
|May 13, 2024
概括
脱水引发了对尿素和氨基酸生产的代谢转变,这与肌肉消耗和长期身体虚弱有关. 这种"估计反应"在一个新的队列中得到了验证,并观察到潜在的性别差异.
科学领域:
- 生理学 生理学 生理学
- 代谢医学是一种代谢医学.
- 生物化学 生物化学
背景情况:
- 高血压脱水与肌肉消耗和有机奥斯莫利特合成有关.
- 之前的研究表明,COVID-19患者的新陈代谢转向氨基酸生产和尿素循环激活,类似于化反应.
研究的目的:
- 为了验证代谢转变和与非COVID队列中的脱水相关的长期身体结果,来自Biobanque Québécoise de la COVID-19 (BQC19).
- 调查脱水严重程度与死亡率,侵入性机械呼吸,急性损伤以及长期身体和精神症状之间的相关性.
主要方法:
- 从BQC19队列中分析了824名患者.
- 包括571名患有脱水数据的患者 (估计的度 - eOSM) 和284名患有代谢组数据和长期随访的患者.
- eOSM与临床结果和代谢概况的相关性,包括性别分层分析.
主要成果:
- 较高的eOSM与尿素和葡萄糖比例增加以及氨基酸丰富相关,与COVID-19患者观察到的aestivation反应一致.
- 严重脱水与增加的死亡率,需要侵入性机械呼吸和急性疾病期间急性损伤有关.
- 在对共变量进行调整后,更严重的脱水显著与长期的身体症状有关,但与精神症状无关. 性别分层分析表明,女性的升高反应可能较弱.
结论:
- 脱水,以增加的eOSM表示,与更严重的急性疾病和长期增加的身体症状有关,这表明脱水引起的肌肉衰竭.
- 这项研究验证了在一个新的队列中对脱水产生类似于化的代谢反应,其特点是氨基酸和尿素的产生.
- 进一步的研究是有必要的,以探索脱水和缓解反应的性别分层差异.
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