双刺激响应向上转换纳米粒子聚-N-异烯胺/DNA核心外微凝.
Qi Gao1, Xiaowen Wang1, Shanjin Hu1
1Research Center for Analytical Sciences, Tianjin Key Laboratory of Biosensing and Molecular Recognition, College of Chemistry, Nankai University, Tianjin 300071, P. R. China; Smart Sensing Interdisciplinary Science Center, School of Materials Science and Engineering, Nankai University, Tianjin 300350, P. R. China. weiweiguo@nankai.edu.cn.
Soft matter
|May 13, 2024
概括
新的刺激反应微凝结合了上转化纳米粒子 (UCNPs) 和DNA,用于智能药物输送. 这些UCNP-pNIPAM/DNA微凝提供可调节尺寸和可编程功能,通过光和温度控制.
科学领域:
- 材料科学 材料科学 材料科学
- 纳米技术 纳米技术
- 生物技术是生物技术.
背景情况:
- 上转化纳米粒子 (UCNPs) 提供独特的近红外 (NIR) 响应特性.
- 聚-N-异烯胺 (pNIPAM) 是一种众所周知的热敏聚合物.
- DNA纳米技术可以精确控制分子功能.
研究的目的:
- 准备具有刺激反应的核心微凝,集成UCNP,PNIPAM和DNA.
- 为了实现可调节的微凝尺寸和可编程的功能.
- 通过使用外部刺激来实现DNA活动的智能调节.
主要方法:
- 合成UCNP-pNIPAM/DNA核心外微凝的合成.
- 微凝尺寸和形态的表征.
- 评估DNA加载效率和活动.
- 对NIR和温度触发的DNA调节的评估.
主要成果:
- 成功制备了UCNP-pNIPAM/DNA核心外微凝,尺寸可调.
- 在微凝中实现了高DNA活性和加载效率.
- 通过NIR照明和温度同时调节DNA活动.
- UCNP 芯提供 NIR 响应,而 pNIPAM 提供热敏度.
结论:
- 开发的微凝表现出极好的刺激反应行为,用于控制DNA释放和活性.
- 这些智能微凝对药物输送和诊断的先进应用具有前途.
- UCNPs,pNIPAM和DNA的组合为功能纳米材料提供了一个多功能平台.
相关概念视频
Nuclear Overhauser Enhancement (NOE)
1.3K
Irradiation of a spin-active nucleus causes an increase or decrease in the signal intensity of neighboring nuclei that are not necessarily chemically bonded or involved in J-coupling. This phenomenon, called the nuclear Overhauser enhancement (NOE), results from through-space interactions between the nuclear spins. The NOE effect decreases with increasing internuclear distance and is generally not observed beyond 4 angstroms. In NOE, dipole-dipole interactions between neighboring spin-active...
1.3K
Insensitive Nuclei Enhanced by Polarization Transfer (INEPT)
1.2K
Insensitive Nuclei Enhanced by Polarization Transfer (INEPT) is an advanced Nuclear Magnetic Resonance (NMR) technique specifically designed to detect and enhance the signals of low-abundance nuclei, such as carbon-13 and nitrogen-15, in small molecules. The fundamental principle behind INEPT is the transfer of polarization from a more abundant and highly polarizable nucleus, typically hydrogen-1, to the low-abundance nucleus of interest. This process effectively boosts the NMR signal of the...
1.2K
Double Resonance Techniques: Overview
870
Double resonance techniques in Nuclear Magnetic Resonance (NMR) spectroscopy involve the simultaneous application of two different frequencies or radiofrequency pulses to manipulate and observe two distinct nuclear spins. One important application of double resonance is spin decoupling, which selectively suppresses coupling with one type of nucleus while observing the NMR signal from another nucleus, simplifying the spectrum and enhancing resolution.
Spin decoupling is usually achieved by...
Spin decoupling is usually achieved by...
870


