根据出生月份对美国婴儿呼吸道共囊病毒的风险分析
Jason R Gantenberg1,2, Robertus van Aalst1,3,4, Monika Reddy Bhuma1
1Department of Health Services, Policy and Practice, Brown University School of Public Health, Providence, Rhode Island, USA.
Journal of the Pediatric Infectious Diseases Society
|May 13, 2024
概括
春晚/夏天出生的婴儿面临着医疗护理的RSV下呼吸道感染的更高风险. 尼尔西维玛可以帮助保护婴儿,特别是那些在RSV季节结束时出生的婴儿.
科学领域:
- 儿科 儿科 儿科
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 呼吸道同胞病毒 (RSV) 在美国显著影响婴儿发病率和死亡率.
- 婴儿的出生月份会影响他们的年龄和第一次接触RSV的时间.
- 了解出生月份特定的风险对于有针对性的预防策略至关重要.
研究的目的:
- 根据婴儿出生月份,估计医疗护理 (MA) RSV下呼吸道感染 (LRTI) 的风险.
- 分析第一个RSV季节和生命的第一年 (FYOL) 的风险.
主要方法:
- 对2016年7月至2020年2月出生的婴儿的三个美国保险索赔数据库 (商业和医疗补助) 的分析.
- 使用诊断编码算法,根据护理水平 (门诊,ED,住院) 将MA RSV LRTI情节分类.
- 主要分析侧重于第一个RSV季节;次要分析比较第一个季节与FYOL风险.
主要成果:
- 出生于5月至9月的婴儿患上第一季MA RSV LRTI的风险最高 (6-26%取决于诊断定义).
- 10月至12月出生的婴儿在第一季RSV相关住院的风险最高.
- 在整个FYOL中,MA RSV LRTI的总体风险在出生月份 (6-30%) 中是可比的,许多病例在门诊或EDS中得到管理.
结论:
- 调查结果支持美国婴儿的nirsevimab建议.
- 在第二个RSV季节之前给予nirsevimab可能会减少未先治疗的婴儿的门诊和ED访问.
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