在早期糖尿病中检测微血管变化的光学连贯性断层扫描血管学:系统性审查和元分析
Fan Yang1, Weijie Zou2, Zhiwei Li3
1Department of Ophthalmology, Second Affiliated Hospital of Soochow University, Suzhou, China.
Diabetes/metabolism research and reviews
|May 13, 2024
概括
光学连贯断层扫描血管学 (OCTA) 能够有效地检测糖尿病视网膜病变患者的早期微血管变化. 表面和深层毛细血管的血管密度变化是关键指标,而在早期阶段,状血管区域的变化不那么显著.
科学领域:
- 眼科医生 眼科 眼科
- 医疗成像医学成像
- 糖尿病视网膜病变研究研究
背景情况:
- 糖尿病微血管变化可以先于临床视网膜病变.
- 早期发现这些变化对于及时干预至关重要.
- 光学连贯断层扫描血管造影 (OCTA) 提供了视网膜血管系统的高分辨率成像.
研究的目的:
- 评估OCTA在检测糖尿病患者早期眼内微血管变化的有效性.
- 在糖尿病视网膜病变的不同阶段评估OCTA参数,如血管密度和状血管区域.
主要方法:
- 在PubMed,Medline,Embase和Cochrane图书馆进行系统的文献搜索 (2012年1月至2023年3月).
- 对照性研究的元分析,将糖尿病患者 (NDR,轻度NPDR) 与健康个体进行比较.
- 对OCTA参数的分析:状血管区域 (FAZ),表面毛细血管 (VDscp),深毛细血管 (VDdcp) 和周毛细血管VD的血管密度.
主要成果:
- 与健康对照人群相比,OCTA在非糖尿病视网膜病变 (NDR) 患者中发现了VDscp,VDdcp和周围皮视网膜病变的显著早期变化.
- 在NDR患者和健康个体之间没有观察到总FAZ的显著差异.
- 与健康个体相比,轻度非增殖性糖尿病视网膜病变 (轻度NPDR) 患者在VDscp,VDdcp和总FAZ中表现出明显的变化.
结论:
- 包括VDscp,VDdcp和周囊血管密度在内的OCTA参数显示出在糖尿病患者中监测早期视网膜微血管病变的潜在生物标志物.
- 在没有视网膜病变的糖尿病患者中,总FAZ可能不是显著的指标.
关键词:
深层的毛细血管.糖尿病视网膜病变 糖尿病视网膜病变足骨非血管区 (FOVAL AVASCULAR ZONE) 是指足骨非血管区 (FOVAL AVASCULAR ZONE) 是指足骨非血管区 (FOVAL AVASCULAR ZONE) 是指足骨非血管区域 (FOVAL AVASCULAR ZONE) 是指足骨非血管区域 (FOVAL AVASCULAR ZONE) 是指足骨非血管区域 (FOVAL AVASCULAR ZONE) 是指足骨非血管区域 (FOVAL AVASCULAR ZONE) 是指足骨非血管区域 (FOVAL AVASCULAR ZONE) 是指足骨非血管区域 (FOVAL光学连贯性断层扫描血管图谱表面的毛细血管.相关概念视频
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