在血造细胞干细胞移植后的二次口腔状细胞癌
Faaris Zaki1, Martina Shephard2, Robert Danby1,3
1Oxford University Hospitals NHS Foundation Trust, Oxford, UK.
Clinical and experimental dermatology
|May 13, 2024
概括
接受血造干细胞移植 (HSCT) 的患者面临口腔状细胞癌 (SCC) 的显著风险,特别是那些患有慢性移植对宿主疾病 (cGVHD) 的患者. 定期的口腔监测对于早期检测和改善这一高风险人群的结果至关重要.
科学领域:
- 在瘤学瘤学.
- 血液学 血液学 血液学
- 移植医学 移植医学
背景情况:
- 血造干细胞移植 (HSCT) 接受者有患二次恶性瘤的风险.
- 口腔状细胞癌 (SCC) 是一种罕见但严重的HSCT后并发症.
- 慢性移植对宿主疾病 (cGVHD) 是已知的SCC发展的风险因素.
研究的目的:
- 描述HSCT患者口服SCC的临床特征,管理和结果.
- 要强调延迟期和与cGVHD的关联.
- 突出需要警监控协议的需要.
主要方法:
- 在HSCT后被诊断患有口腔SCC的10名患者的回顾性病例系列.
- 临床数据的审查,包括HSCT的延迟时间,GVHD病史,临床表现,分期,治疗和随访.
- 对死亡率和生存数据的分析.
主要成果:
- 从HSCT到口服SCC诊断的中位延迟时间为10年.
- 90%的患者有cGVHD病史;40%的患者有活跃的严重口服GvHD.
- 常见的部位包括舌头和口腔粘膜;管理涉及手术+/-化疗/放射治疗.
- 随访时间中位数为1年,总死亡率为50%,SCC特异性死亡率为30%.
结论:
- 口腔SCC是HSCT幸存者的一个重大问题,通常与cGVHD有关.
- 通过在专业诊所定期进行口腔和皮肤监测,及早检测至关重要.
- 无论GVHD的严重程度或免疫抑制的持续时间,都应该保持监测.
更多相关视频
相关概念视频
01:21Stem Cell Therapy for Tissue Regeneration
4.0K
Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
4.0K
01:01Regulation of Hematopoietic Stem Cells
3.2K
All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
3.2K
01:22Bone Marrow Sampling and Transplants
325
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
325
01:19Multipotency of Hematopoietic Stem Cells
3.1K
The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
3.1K
02:40Cancer Stem Cells and Tumor Maintenance
4.9K
Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
4.9K