在急性中风中血压变化:风险因素和1个月后与功能结果的关联
Catriona Reddin1,2, Robert Murphy1, Graeme J Hankey3,4
1HRB Clinical Research Facility Galway, School of Medicine, University of Galway, Galway, Ireland.
European journal of neurology
|May 13, 2024
概括
在急性中风中增加的血压变化与更糟糕的功能结果有关. 尿液中的低分泌量是这种变化的可修改风险因素,提供了潜在的干预目标.
科学领域:
- 神经学 神经学
- 心血管医学 心血管医学
- 公共卫生 公共卫生
背景情况:
- 在急性中风中,血压变化 (BPV) 是影响功能结果的潜在可修改因素.
- 了解BPV及其决定因素对于改善中风后恢复至关重要.
研究的目的:
- 确定早期血压变化和功能结果在一个大型国际急性中风队列之间的关联.
- 确定导致中风后血压变化增加的危险因素.
主要方法:
- 使用了INTERSTROKE国际病例控制研究的数据.
- 录取时,第二天早上和采访时记录的血压;计算的标准偏差 (SD) 和方差系数.
- 采用多变量顺序和后勤回归来分析BPV与功能结果的关联 (修改的兰金得分) 并确定风险因素.
主要成果:
- 分析了13,206名参与者;平均年龄为62.19岁.
- 缩性BPV (SD ≥20 mmHg) 和腹缩性BPV (SD ≥10 mmHg) 与功能性结果差的几率增加显著相关.
- 增加BPV的危险因素包括年龄较大,女性性别,高BMI,高血压史,酒精使用,尿中的低和尿中的高.
结论:
- 在急性中风中通过SD测量的高血压变化,与一个月后功能表现不佳的风险更高相关.
- 尿液中的低分泌被确定为增加血压变异性的潜在可修改的危险因素.
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