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5'-Methoxyarmillane,一个生物活性的Sesquiterpenoid 酸乙从真菌 Armillaria ostoyae

Axel M Orban¹, Johanna Eichberg¹, Michael Marner¹

¹Fraunhofer Institute for Molecular Biology and Applied Ecology IME, Bioresources, 35392, Giessen, Germany.

Chembiochem : a European journal of chemical biology

|May 13, 2024

概括

研究人员发现了一种新的melleolide,5'-methoxyarmillane,来自Armillaria ostoyae真菌. 这种化合物显示出作为抗癌剂和抗结核病的潜力,其产量由菜油增强.

科学领域:

菌类学菌类学是指菌类学.
自然产品化学化学
药理学药理学是指药理学的学科.

背景情况:

亚米拉里亚 (Basidiomycota) 属中较高的真菌是已知的生物活性的melleolides的生产者.
梅列奥利德是具有多种生物活性的基烯酸烯酸.

研究的目的:

为了识别和描述来自Armillaria ostoyae的新生物活性化合物.
评估孤立化合物的细胞毒性和抗微生物潜力.

主要方法:

从Armillaria ostoyae mycelium中进行生物活性引导的分离.
使用UHPLC-QTOF-HR-MS/MS和NMR光谱学的结构阐明.
在体外检测细胞毒性和抗菌活性.

主要成果:

一种新的melleolide,5-methoxyarmillane (1),被确定.
化合物1对Madin-Darby犬II和人类肺癌Calu-3细胞表现出显著的毒性.
对 Mycobacterium tuberculosis 和 Mycobacterium smegmatis 观察到适度的活动,但对其他测试的细菌,真菌或病毒没有.

结论:

5 - - 甲氧亚米兰是一种新型的生物活性甲化物,具有有前途的抗癌和抗菌特性.
油菜油补充剂显著提高了5-甲亚米兰的产量.
进一步研究melleolides可能会导致新的治疗药物.

关键词:

细胞毒性细胞毒性梅尔叶化物是什么意思类是一种真菌.这是Mycobacterium.类物质是指类物质.

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