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Updated: Jul 27, 2026

Purification and Aggregation of the Amyloid Precursor Protein Intracellular Domain
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聚合扫描4D:对依赖pH的蛋白质聚合的结构知情分析.

Oriol Bárcenas1, Aleksander Kuriata2, Mateusz Zalewski2

  • 1Institut de Biotecnologia i de Biomedicina and Departament de Bioquímica i Biologia Molecular, Universitat Autònoma de Barcelona, 08193 Bellaterra, Barcelona, Spain.

Nucleic acids research
|May 13, 2024
PubMed
概括

使用进化方法,Aggrescan4D (A4D) 预测了依赖pH值的蛋白质聚合和工程师的溶解度. 该工具有助于理解和设计解决疾病和生物技术中的蛋白质聚合挑战的解决方案.

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相关概念视频

Protein Organization01:24

Protein Organization

Proteins are polymers of amino acid residues. They are versatile and responsible for different cellular functions, including DNA replication, molecular transport, catalysis, and structural support. Proteins have a hierarchical structure comprising at least three levels of organization: primary, secondary, and tertiary structure. Some large proteins have a quaternary structure where individual protein subunits are linked together.
The primary structure of a protein is its amino acid sequence.