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体重变化与炎症性肠病之间的关系. 一个基于人口的队列研究,HUNT研究
Martin Campo1, Heidi Hjelle1,2, Atle van Beelen Granlund3,4,5
1HUNT Research Centre, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Levanger, Norway.
Scandinavian journal of gastroenterology
|May 13, 2024
概括
减肥可能会降低患性结肠炎 (UC) 的风险,但似乎会增加克罗恩氏病的风险.
科学领域:
- 胃肠病学 胃肠病学
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 炎症性肠病 (IBD) 的发病率上升与超重和肥胖率的上升并行.
- 肥胖可能是IBD发展的一个因素.
研究的目的:
- 调查体重变化与随后患IBD的风险之间的关联.
- 为了确定人口体重的增加是否可以解释IBD发病率的上升.
主要方法:
- 利用了挪威 (1984-2008) 三项特伦德拉格健康研究 (HUNT1-3) 中55896名成年参与者的数据.
- 在研究期间之间评估身体质量指数 (BMI) 的变化作为暴露.
- 在使用考克斯回归分析的十年随访期间监测新的IBD诊断.
主要成果:
- 体重减轻与38%降低了新的性结肠炎 (UC) 诊断的风险 (aHR 0.62).
- 体重减轻似乎使得克罗恩病 (CD) 新诊断的风险增加了一倍 (aHR 2.01).
- 体重增加和UC或CD的新诊断之间没有发现显著的关联.
结论:
- 体重减轻与UC风险降低有关.
- 体重增加和IBD风险之间缺乏关联表明,增加人口体重并不能解释IBD发病率的上升.
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