从古代人类口腔微生物组推断出饮食,疾病和抗生素耐药性
Gwyn Dahlquist-Axe1, Francesca J Standeven1, Camilla F Speller2
1School of Chemistry and Biosciences, University of Bradford, Bradford, UK.
Microbial genomics
|May 13, 2024
概括
人口微生物组随着社会变化而演变,自从广泛使用抗生素以来,观察到抗生素耐药性基因的增加. 需要进一步的历史研究,以了解口腔微生物群的演变,并打击现代抗药性.
科学领域:
- 微生物学 微生物学
- 进化生物学 进化生物学
- 考古学的考古学
背景情况:
- 人的微生物群,特别是口腔微生物群,显著影响健康和疾病.
- 口腔微生物组含有病原体和抗生素耐药性基因.
- 对人类口腔环境和微生物群的历史影响仍未得到充分研究.
研究的目的:
- 审查塑造人类口腔环境和相关细菌群落的历史和史前事件.
- 概述口腔微生物群进化与重大社会/行为变化之间的联系.
- 识别有关口服抗菌素耐药性演变的知识差距.
主要方法:
- 文献综述和现有研究的综合.
- 描述影响口腔环境的历史事件.
- 分析与抗菌素耐药性相关的生物分子考古证据.
主要成果:
- 社会转变 (新石器时代前,农业,工业革命,抗生素时代) 影响了口腔微生物群.
- 有证据表明,抗生素出现后,口服抗菌素耐药性基因的增加.
- 在了解口服抗菌素耐药性的历史流行和演变方面存在重大差距.
结论:
- 人口微生物组经历了由历史事件驱动的进化变化.
- 现代抗生素的使用显然增加了口腔微生物群中的抗菌素耐药性基因.
- 历史研究对于开发针对当代抗微生物药物耐药性的有效策略至关重要.
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