自然产品在炎症中的潜力:生物活动,结构-活动关系和机械目标
Yajing Guo1, Xuling Peng1, Fanfei Liu1
1School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, 10 Poyanghu Road, Jinghai District, Tianjin, 301617, People's Republic of China.
Archives of pharmacal research
|May 13, 2024
概括
由于当前药物的不良影响,开发新的抗炎药物至关重要. 本综述探讨了260种天然产品及其衍生物,以获得更安全,更有效的抗炎疗法.
科学领域:
- 药理学和天然产品化学
背景情况:
- 炎症是一种关键的身体过程,但其调节失调可能会造成重大损害.
- 目前的抗炎药物,包括非类固醇抗炎药物 (NSAID) 和类固醇激素,具有显著的副作用,需要更安全的替代品.
- 自然产品是开发新型抗炎药物的有希望的途径,因为它们的结构和活动各不相同.
研究的目的:
- 审查过去二十年中发现的具有抗炎作用的天然产品及其衍生物.
- 分析这些化合物的结构-活性关系 (SAR) 的抗炎性潜力.
- 通过网络药理学探索天然产品的作用机制.
主要方法:
- 在过去的20年中,对已报告具有抗炎活性的天然产品进行了全面的文献搜索.
- 根据其活性成分对已识别的天然产品进行分类.
- 分析与抗炎作用相关的结构-活性关系.
- 网络药理学预测以阐明抗炎机制和途径.
主要成果:
- 一个汇编的260种天然产品及其衍生品展现抗炎性质.
- 详细了解这些天然化合物的SAR,强调抗炎活性的关键结构特征.
- 识别潜在的分子点和途径,涉及到天然产品的抗炎作用.
结论:
- 自然产品是开发新的,更安全,更有效的抗炎药物的丰富来源.
- 了解SAR对于合理的药物设计和优化基于天然产品的抗炎药物至关重要.
- 网络药理学为揭示这些化合物的治疗潜力背后的复杂机制提供了有价值的框架.
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