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胚胎发育和活产在以前失败过一次完整IVF/ICSI周期的妇女身上
Wen Wen1, Dian Zhang1,2, Xiaohua Liu1
1Assisted Reproduction Center, Northwest Women's and Children's Hospital, Houzaimen North Street, Xi'an, 73#, China.
Journal of assisted reproduction and genetics
|May 13, 2024
概括
在初始失败后接受第二次体外受精 (IVF) 周期的女性表现出改善的胚胎结果. 然而,活产率 (LBRs) 在第二个周期较低,表明植入和活产的持续挑战.
科学领域:
- 生殖医学 生殖医学
- 在体外受精 (IVF)
- 胚胎学 胚胎学
背景情况:
- 许多妇女经历了第一次不成功的体外受精 (IVF) 周期.
- 了解后续试管婴儿试验的结果对于患者咨询和治疗计划至关重要.
研究的目的:
- 评估试图在第一次失败后尝试第二次试管婴儿周期的妇女的胚胎和怀孕结果.
- 为了比较第二次试管婴儿周期与第一周期的活产率 (LBR).
主要方法:
- 分析了1227名女性的队列,这些妇女在第一次试管婴儿周期中失败并进行了第二次尝试,以分析胚胎学结果.
- 包括LBR在内的生殖结果与1227名接受第二次试管婴儿周期的妇女和13195名接受第一轮胚胎细胞培养的妇女进行了比较.
主要成果:
- 与第一个周期相比,第二次试管婴儿周期显示出明显更高的检索卵细胞,受精卵细胞,可使用的胚胎和胚胎细胞的中位数.
- 在第二个周期中,胚胎细胞形成率显著增加,从33%增加到50%.
- 然而,初级转移活产率 (LBRs) 在第二个周期 (40.82%) 与初始周期 (51.79%) 相比显著下降.
结论:
- 第二次试管婴儿试验显示了实验室和胚胎学结果的显著改善.
- 尽管实验室性能提高了,但活产率仍然是一个挑战,突出了植入和怀孕进展的问题.
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