心血管结构和功能参数在异常性肺纤维化在疾病诊断的疾病诊断
Paola Faverio1,2, Alessandro Maloberti3,4, Paola Rebora5
1U.O.C. di Pneumologia, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico San Gerardo dei Tintori, Monza, Italy.
概括
异形性肺纤维化 (IPF) 患者在疾病早期表现出类似于健康个体的心脏和血管纤维化. 需要进一步的研究来了解IPF中心血管参与的进展.
科学领域:
- 心脏病学 心脏病学
- 肺部病理学 肺部病理学
- 血管医学 血管医学
背景情况:
- 在异形性肺纤维化 (IPF) 中心血管纤维化的患病率尚未得到充分确立.
- 对心血管参与的早期IPF评估至关重要.
研究的目的:
- 为了比较心脏和血管功能和结构性质在IPF患者与健康对照.
- 探索IPF中疾病严重程度和心血管参数之间的关系.
主要方法:
- 心声图和NT-pro-brain natriuretic用于心脏功能 (心脏衰竭,腹功能障碍).
- 流介延伸 (FMD) 和脉冲波速度 (PWV) 用于血管功能 (内皮功能,动脉硬).
- 50名IPF患者 (抗纤维素治疗前) 和50名年龄/性别匹配的对照组.
主要成果:
- 在IPF患者中,83.8%的患者表现出透支功能障碍,37.8%的患者表现出心力衰竭,76.6%的患者表现出血管纤维化.
- 与对照组 (分别为67.3%,24.5%,84.8%) 相比,扩张性功能障碍,高血压或血管纤维化没有显著差异.
- 疾病严重程度与PWV,口病,腹筋功能障碍或高血压不相关.
结论:
- 与对照组相比,早期的IPF患者没有显著的心血管纤维化参与.
- 需要进行更大规模的研究来验证这些初步发现.
- 长度研究是必要的,以确定IPF心血管问题的发病和进展.
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