脂蛋白的影响 (a) 水平对心血管风险估计水平
Walter Masson1,2, Gabriel Waisman3, Pablo Corral4,5
1Department of Cardiology, Hospital Italiano de Buenos Aires, Perón 4190, C1199ABB, Ciudad Autónoma de Buenos Aires, Argentina. walter.masson@hospitalitaliano.org.ar.
概括
结合脂蛋白 (Lp) 的新型心血管风险计算器显著影响了风险评估. 降低LDL-C或SBP可以有效地减轻许多患者的Lp(a) ]相关风险.
科学领域:
- 心脏病学 心脏病学
- 预防医学 预防医学
- 脂质学 脂质学是指脂质学.
背景情况:
- 开发了一种新型的心血管风险 (CVR) 计算器,集成脂蛋白 (Lp) 水平.
- 升高的Lp (a) 是心血管疾病的独立风险因素.
研究的目的:
- 为了估计CVR使用新的Lp(a) 包括分数.
- 确定降低低密度脂蛋白胆固醇 (LDL-C) 或压缩血压 (SBP) 的必要降低,以抵消由Lp驱动的风险.
主要方法:
- 在初级预防患者的终身和10年风险中,使用新的得分计算CVR,包括和没有Lp (a) 值.
- 当Lp (a) 增加CVR时,需要减少LDL-C或SBP来平衡这种风险时,这些风险被计算出来.
主要成果:
- 这项研究包括671名患者;22.7%的Lp (a) 水平高 (>50 mg/dL或>125 nmol/L).
- 整合Lp (a) 在66.7%的病例中增加了终身CVR (中位数为19.3%),对于10年风险也有类似的趋势.
- 从Lp (a) 的风险上升被79.2%的患者的平均LDL-C降低21 mg/dL或74.7%的患者的SBP降低6.3 mmHg所抵消.
结论:
- 新的得分导致了三分之二和三分之一的人群的双向风险重新分类.
- 降低LDL-C或SBP有效地减轻了与Lp升高相关的心血管风险增加,在很大一部分患者中.
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