在euryhaline鱼的状离子细胞功能的内分泌控制
Jason P Breves1, Ciaran A Shaughnessy2
1Department of Biology, Skidmore College, 815 N. Broadway, Saratoga Springs, NY, 12866, USA. jbreves@skidmore.edu.
概括
荷尔蒙调节鱼的关键细胞功能,使它们能够适应不同的盐分水平. 本综述详细介绍了荷尔蒙如何控制欧鱼中水矿平衡的离子细胞.
科学领域:
- *水生脊椎动物的内分泌学和度调节.
- * 鱼中的离子运输的分子机制.
背景情况:
- * 欧鱼必须在不同的盐度环境中保持水矿平衡.
- * 枝状离子细胞对于活性离子交换 (Na+,Cl-,Ca2+) 和盐度适应至关重要.
- *内分泌系统在调节这些透调节器官方面发挥着至关重要的作用.
研究的目的:
- * 审查将调节激素与分支离子离子运输联系起来的分子机制.
- * 探索激素如何在鱼类离子细胞中指导离子载体表达.
- * 突出研究的荷尔蒙调节在两个teleost和基底鱼系.
主要方法:
- * 对现有关于鱼调节和内分泌学研究的综合文献综述.
- *分析涉及激素,受体和离子运输蛋白质的分子通路.
- * 综合来自远模型的发现和基础系的新兴研究.
主要成果:
- *诸如益生素,生长激素,皮质醇和IGF等激素通过同源受体调节离子细胞功能.
- * 荷尔蒙信号调节离子载体,Na+/K+-ATPases,紧结蛋白和水蛋白的表达.
- *不同的淡水类型 (离子吸收性) 和海水类型 (离子分泌性) 离子细胞受到不同的调节.
结论:
- * 荷尔蒙调节对欧鱼的离子细胞功能和盐度适应至关重要.
- *了解这些通路对于理解鱼类水矿平衡至关重要.
- *需要进一步的研究,以充分阐明基于离子细胞的透调节中的荷尔蒙信号,特别是在基底系.
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