低剂量铁补充对母乳养婴儿早期发育的影响:一项随机临床试验
Ludwig Svensson1, Grzegorz Chmielewski2, Emilia Czyzewska3
1Department of Clinical Sciences, Pediatrics, Umeå University, Umeå, Sweden.
JAMA pediatrics
|May 13, 2024
概括
4至9个月龄的母乳养婴儿每天服用低剂量的铁补充剂在12个月后没有改善精神运动发育或减少铁缺乏症. 这项研究没有发现对婴儿发育或贫血预防有显著的益处.
科学领域:
- 儿科 儿科 儿科
- 营养科学 营养科学
- 发展心理学 发展心理学
背景情况:
- 母乳养的婴儿面临铁缺乏影响发育的风险.
- 关于补充铁对儿童发育的影响的证据有限,有矛盾的指导方针.
- 低于最佳的婴儿发育是一个与缺铁有关的问题.
研究的目的:
- 为了确定从4到9个月的每日补充铁 (1毫克/公斤) 在12个月的纯母乳或主要母乳养的婴儿中是否能改善精神运动发育.
- 评估补充铁对认知和语言发展的影响.
- 为了评估对缺铁和缺铁性贫血的影响.
主要方法:
- 波兰和瑞典的一项随机,双盲,安慰剂对照试验.
- 参与者:健康的,按期出生的,完全/主要母乳养的婴儿,在4个月没有贫血.
- 干预:每天铁 (1毫克/公斤) 或安慰剂从4个月到9个月;在12,24个月和36个月评估结果.
主要成果:
- 与安慰剂相比,12个月后,补充铁并没有显著改善精神运动 (运动),认知或语言的得分.
- 在24个月和36个月后,发育得分没有显著差异.
- 干预措施并没有降低12个月后缺铁或缺铁性贫血的风险.
结论:
- 从4个月到9个月的每日低剂量铁补充剂 (1毫克/公斤) 对母乳养婴儿的精神运动发育没有好处.
- 补充剂并没有减少这种低风险人群中缺铁或缺铁性贫血的发生率.
- 研究结果表明,目前的补充剂实践可能对这一特定婴儿群体的精神运动发育不有益.
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