丹麦心血管查 (DANCAVAS) 试验的用户定义结果:对基于人口的随机对照试验的特异分析
Axel Cosmus Pyndt Diederichsen1, Anna Mejldal2, Rikke Søgaard3
1Department of Cardiology, Odense University Hospital, Odense, Denmark.
PLoS medicine
|May 13, 2024
概括
65-74岁男性的心血管查减少了中风和心肌梗塞,但略有增加了内出血风险. 这项研究分析了患者的偏好和丹麦心血管查 (DANCAVAS) 试验的结果.
科学领域:
- 心脏病学 心脏病学
- 预防医学 预防医学
- 公共卫生 公共卫生
背景情况:
- 丹麦心血管查 (DANCAVAS) 试验调查了查对男性死亡率的影响,但没有成功.
- 患者对查结果的偏好可能有所不同,需要进一步调查.
- 这项研究重点关注65-74岁的男性,这是评估心血管风险的特定人口群体.
研究的目的:
- 为了确定65-74岁的男性是否选择基于CT的心血管查.
- 评估查对患者偏好优先考虑的结果的影响.
- 评估基于CT的查在这个年龄组的有效性和安全性.
主要方法:
- 随机DANCAVAS试验的后期分析,涉及65-74岁的男性.
- 随机分配到邀请查或通常的护理组.
- 通过调查评估患者的偏好;在意向选的基础上分析结果.
主要成果:
- 查降低了中风和心肌梗塞的风险 (HR 0.93,p=0.010).
- 观察到内出血的风险增加 (HR 1.17,p=0.029).
- 在严重的胃肠道出血或心血管外科手术后死亡率上没有显著差异.
结论:
- 在65-74岁的男性中,基于CT的心血管查减少了中风和心肌梗塞.
- 查计划与内出血风险的小幅增加有关.
- 这些发现仅限于65-74岁的男性,不能将其推广到其他人口统计学群体.
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