相关实验视频

Updated: May 5, 2026

Custom-designed Laser-based Heating Apparatus for Triggered Release of Cisplatin from Thermosensitive Liposomes with Magnetic Resonance Image Guidance

Custom-designed Laser-based Heating Apparatus for Triggered Release of Cisplatin from Thermosensitive Liposomes with Magnetic Resonance Image Guidance

Published on: December 13, 2015

瘤向氧沙 (Oxaliplatin) 的产药配送基于ROS调节的癌症选择性甘氨酸标签

Jiajia Wang¹, Wei Cao¹, Wei Zhang²

¹Joint National Laboratory for Antibody Drug Engineering, The First Affiliated Hospital of Henan University, Henan University, Kaifeng 475000, China.

Journal of medicinal chemistry

|May 13, 2024

概括

这项研究引入了一种针对癌症治疗的新型反应性氧物种调节探针 (B-Ac3ManNAz). 它增强了oxaliplatin向瘤的输送,减少了化疗的副作用.

科学领域:

生物化学生物化学
化学生物学化学生物学
在瘤学瘤学.

背景情况:

药化学疗法是有效的,但导致严重的目标外毒性.
代谢性甘氨酸标签提供瘤向治疗,但缺乏体内选择性.
反应性氧物种 (ROS) 在瘤细胞中被上调,成为治疗点.

研究的目的:

开发一种新的代谢前体探针 (B-Ac3ManNAz),用于ROS调节的瘤特异性甘氨酸标签.
为了提高DBCO修饰的氧化的向输送和疗效 (IV) 使用生物对等化学.
为了减少化疗在正常组织中的非目标毒性.

主要方法:

从Ac4ManNAz和HBAPE中合成B-Ac3ManNAz,证实了ROS调节.
通过B-Ac3ManNAz对细胞表面进行强大的甘氨酸标记的演示.
使用点击化学,将DBCO修饰的氧化 (Oxaliplatin) 连接到阿化修饰的瘤细胞.

主要成果:

B-Ac3ManNAz成功合成,并被证明是ROS调节的.
该探针有效标记了细胞表面的甘氨酸,从而实现了向治疗.
在N3治疗的瘤细胞中,DBCO-oxaliplatin (IV) 的积累增加,而非点分布则减少.

结论:

B-Ac3ManNAz作为一种有效的代谢前体,用于瘤特异性甘氨酸标记.
这一策略通过改善药物积累和减少副作用来增强向癌症治疗.
通过ROS调节的生物对等方法为选择性化疗提供了一个有前途的途径.

更多相关视频

Pretargeted Radioimmunotherapy Based on the Inverse Electron Demand Diels-Alder Reaction

Pretargeted Radioimmunotherapy Based on the Inverse Electron Demand Diels-Alder Reaction

Published on: January 29, 2019

Author Spotlight: Innovative Cancer Therapies with Iron Oxide Nanoparticles for Glioblastoma Treatment

Author Spotlight: Innovative Cancer Therapies with Iron Oxide Nanoparticles for Glioblastoma Treatment

Published on: September 27, 2024

相关概念视频

Targeted Cancer Therapies

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...

Modified-Release Drug Delivery Systems: Site-Targeted

Modified-Release Drug Delivery Systems: Site-Targeted

Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.