在PCOS中对比骨形状与BMI有关:系统性审查和元分析
Graziela Rissetti1, Julia Mottecy Piovezan1, Melissa Orlandin Premaor2
1Department of Clinical Medicine, Faculty of Medicine, Federal University of Santa Maria, Santa Maria, RS 97105-900, Brazil.
The Journal of clinical endocrinology and metabolism
|May 13, 2024
概括
多囊卵巢综合征 (PCOS) 与骨密度变化有关. 患有PCOS和较低BMI (<27 kg/m2) 的女性表现出骨质减少和吸收增加,表明潜在的骨脆弱.
科学领域:
- 内分泌学 在内分泌学.
- 骨的新陈代谢 骨的新陈代谢
- 生殖健康 生殖健康
背景情况:
- 关于多囊性卵巢综合征 (PCOS) 是否保护或增加骨脆弱的风险,存在相互矛盾的证据.
- 这一元分析更新了以前关于PCOS和骨健康的研究结果.
研究的目的:
- 研究多囊性卵巢综合征 (PCOS) 对绝经前妇女骨参数的影响.
- 为2018年至2023年间发表的研究提供最新的元分析.
主要方法:
- 在MEDLINE和Embase数据库中的系统文献搜索.
- 包括以英语 (2018-2023) 出版的符合特定PCOS诊断标准和质量标准的研究 (纽卡斯尔-太华尺度≥6).
- 数据由两个独立的审稿人提取.
主要成果:
- 分析了31项研究 (1822个PCOS,1374个对照在横截面;30305个PCOS,101907个对照在队列).
- 根据身体质量指数 (BMI) 的分层揭示了不同的骨形状.
- 患有BMI<27 kg/m2的PCOS:骨密度较低,骨形成减少 (骨质卡尔),骨再吸收增加 (C端I型原蛋白).
- 具有BMI≥27kg/m2的PCOS:骨密度增加,骨循环标志物没有显著变化 (除骨素).
结论:
- 绝经前妇女的PCOS,BMI<27 kg/m2与低骨质量有关.
- 这一小组表现出低骨质形成和增加的骨质再吸收,这表明骨脆弱的风险增加.
- 需要进一步的研究来阐明PCOS,BMI和骨健康之间的复杂关系.
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