甲状腺切除术对原发性甲状腺功能障碍症患者的骨影响:系统性审查和元分析
Nattanan Kongsaree1, Thanaporn Thanyajaroen1, Bothamai Dechates2
1Princess Srisavangavadhana College of Medicine, Chulabhorn Royal Academy, Bangkok 10210, Thailand.
The Journal of clinical endocrinology and metabolism
|May 13, 2024
概括
副甲状腺切除术 (PTX) 显著降低了原发性副甲状腺症 (PHPT) 患者的骨折风险. 这种手术的好处不仅仅是改善骨矿物质密度,还可以减少整体和部骨折.
科学领域:
- 内分泌学 在内分泌学.
- 整形外科 整形外科 整形外科
- 手术瘤学手术瘤学
背景情况:
- 原发性甲状腺功能增强症 (PHPT) 通常用甲状腺切除术 (PTX) 治疗.
- PTX对PHPT患者骨折风险降低的确切影响仍在调查中.
- 了解PTX后的骨折风险和骨矿物密度 (BMD) 变化对于患者管理至关重要.
研究的目的:
- 为了比较PTX和观察 (OBS) 的PHPT患者的骨折风险和BMD变化.
- 评估PTX在减轻骨折事件和改善骨健康方面的有效性.
主要方法:
- 在PubMed,Embase和Cochrane图书馆进行系统的文献搜索,截至2022年9月.
- 包括随机对照试验 (RCT) 和队列研究报告骨折事件和/或骨质变化.
- 根据两个独立审查员的PRISMA指南进行数据提取.
主要成果:
- 与OBS相比,PTX显著降低了大量患者队列中的整体骨折风险 (RR,0.80) 和关节骨折风险 (RR,0.63).
- 没有观察到前臂或脊椎骨折的显著减少.
- PTX组在部部,部,半径和脊柱的 BMD 年度增加更高.
结论:
- 副甲状腺切除术有效降低PHPT患者的整体和关节骨折风险.
- 观察到的骨折风险降低表明PTX的好处超越了BMD的改善.
- 在PHPT管理中应考虑PTX,以减少骨并发症.
关键词:
无症状的副甲状腺功能障碍症.骨矿物质密度 骨矿物质密度骨折,骨折,骨折,骨折,骨折,骨折,骨折,骨折,骨折,骨折,骨折,骨折,骨折,骨折,骨折,骨折,骨折,骨折,骨折,骨折,骨折,骨折.轻度的副甲状腺功能障碍症 (轻度的甲状腺功能障碍症)副甲状腺腺瘤 副甲状腺腺瘤副甲状腺过度增生 甲状腺过度增生副甲状腺手术是什么?更多相关视频
07:12Establishment of a Simple and Effective Rat Model for Intraoperative Parathyroid Gland Imaging
Published on: August 17, 2022
3.4K
07:13Two Techniques to Create Hypoparathyroid Mice: Parathyroidectomy Using GFP Glands and Diphtheria-Toxin-Mediated Parathyroid Ablation
Published on: March 14, 2017
14.6K
相关概念视频
01:21Skeleton and Calcium Homeostasis
4.5K
Calcium is not only the most abundant mineral in bone but also the most abundant mineral in the human body. Calcium ions are needed for bone mineralization, tooth health, heart rate regulation and strength of contraction, blood coagulation, the contraction of smooth and skeletal muscle cells, and the regulation of nerve impulse conduction. The average calcium level in the blood is about 10 mg/dL. When the body cannot maintain this level, a person will experience hypo or hypercalcemia.
4.5K
00:59The Parathyroid Glands
2.1K
The two pairs of parathyroid glands embedded within the posterior surface of the thyroid gland are restricted by a dense capsule around them. These glands comprise two distinct cell populations—parathyroid oxyphil and parathyroid principal cells- pivotal in calcium homeostasis.
Oxyphil cells, whose functions remain elusive, emerge during late puberty, adding a layer of complexity to the parathyroid gland's intricacies. In contrast, principal parathyroid cells undertake a vital role by...
Oxyphil cells, whose functions remain elusive, emerge during late puberty, adding a layer of complexity to the parathyroid gland's intricacies. In contrast, principal parathyroid cells undertake a vital role by...
2.1K
01:17Hormones and Bone Tissue
2.7K
The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
2.7K
01:40Bone Remodeling
38.3K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
38.3K
01:29Bone Disorders
3.5K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
3.5K
01:31Osteoclasts in Bone Remodeling
2.9K
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
2.9K