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估计美国的C型肝炎患病率,2017-2020年
Eric W Hall1, Heather Bradley2, Laurie K Barker3
1OHSU-PSU School of Public Health, Oregon Health & Science University, Portland, Oregon, USA.
Hepatology (Baltimore, Md.)
|May 13, 2024
概括
国家健康和营养检查调查 (NHANES) 的数据低估了型肝炎的流行率. 新的模型显示,C型肝炎感染率显著上升,特别是考虑到注射毒品的人 (PWID).
科学领域:
- 流行病学 流行病学
- 公共卫生 公共卫生
- 传染性疾病 传染性疾病
背景情况:
- 国家健康和营养检查调查 (NHANES) 可能低估了美国成年人群中肝炎C病毒 (HCV) 感染的真实患病率.
- 某些人群,如注射毒品的人 (PWID),在像NHANES这样的国家调查中往往代表性不足.
研究的目的:
- 开发和应用两个模型来估计2017-2020年美国成年人中HCV感染的全国流行率.
- 通过考虑在NHANES中不充分代表的人口,提供更准确的HCV流行率估计.
主要方法:
- NHANES+模型:补充了NHANES数据,包括文献综述和对非NHANES人群中HCV患病率的元分析.
- PWID调整模型:纳入成人PWID的估计数量及其特定的HCV流行率,以调整NHANES数据.
主要成果:
- 该NHANES+模型估计HCVRNA的流行率为1.0% (2,463,700例感染).
- 根据PWID调整模型的估计,HCV RNA患病率大幅上升至1.6% (4,043,200例感染).
- 使用可比方法,估计的HCV患病率从2013-2016年保持不变,但在考虑PWID时显著增加.
结论:
- 型肝炎的患病率可能比以前报告的要高,特别是考虑到注射药物使用的增加.
- 需要采取紧急的国家行动,扩大HCV检测,治疗机会和改善监测,特别是在医疗服务不足的人群中.
- 这些努力对于实现国家型肝炎消除目标至关重要.
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