相互透的纳米凝的合成和热诱导的凝
Tingting Xia1, Xueting Li2, Youtong Wu1
1College of Chemistry and Chemical Engineering, Donghua University, 2999 North Renmin Road, Shanghai 201620, China.
Journal of colloid and interface science
|May 13, 2024
概括
研究人员开发了新的相互透 (IPN) 纳米凝,在加热时形成彩色凝. 这些可注射,非细胞毒性纳米凝显示了组织工程和药物输送系统的潜力.
科学领域:
- 聚合物科学与工程 聚合物科学与工程
- 生物材料科学 生物材料科学
- 纳米技术纳米技术
背景情况:
- 可注射的水凝对于微创组织工程和药物输送至关重要.
- 热诱导的in-situ化为体内受控的物质形成提供了优势.
- 开发具有可调节性质的新型纳米凝系统对于先进的生物医学应用至关重要.
研究的目的:
- 合成和描述由聚 (N-异烯烯胺) (PNIPAM) 和聚 (N-烯-l-氨) (PAphe) 组成的新型相互透 (IPN) 纳米凝.
- 研究这些IPN纳米凝的可逆性,温度触发的sol-gel过渡和结构色彩形成.
- 评估各种因素对凝性质的影响,并评估开发的纳米凝的注射性和细胞毒性.
主要方法:
- 合成具有不同PAphe含量的IPN纳米凝.
- 动态光散射 (DLS) 来确定相位过渡温度 (Tp).
- 风湿测量和光纤光谱学用于分析sol-gel过渡期间的风湿学和光学特性.
- 评估可注射性和细胞毒性.
主要成果:
- IPN纳米凝在加热时表现出可逆的sol-gel过渡,高于其相位过渡温度 (Tp),形成结构色凝.
- IPN纳米凝的Tp与PNIPAM一致,并且在生理pH下独立于PAphe含量.
- 凝时间受温度,PAphe成分,度和相互透序列的影响.
- 由于纳米凝收缩,随着温度的增加,观察到布拉格反射峰的蓝色转移.
- IPN纳米凝显示出良好的注射性和没有显著的细胞毒性.
结论:
- 合成的IPN纳米凝为热诱导的in-situ凝提供了一个有前途的平台.
- 这些材料具有调节性质和结构色彩,适合高级应用.
- 开发的纳米凝系统为基于NIPAM的液凝开发在组织工程和药物输送方面开辟了新的途径.
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