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Updated: Jun 26, 2025

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卡米尔1通过通过TRIM27/p53轴激活ERK/mTOR通路来调节肝癌细胞的增殖

Yuzhen Ge1, Benli Xiao2, Rui Zhao3

  • 1Department of Prdiatric Surgery, The Affiliated Hospital of Guizhou Medical University, Guiyang, PR China.

International immunopharmacology
|May 13, 2024
PubMed
概括

封闭蛋白调节因子和肌肉蛋白1链接因子1 (CARMIL1) 通过调节TRIM27/p53轴和ERK/mTOR通路,促进肝癌细胞的增殖. 抑制CARMIL1可以提高肝癌治疗中索拉芬尼的敏感性.

关键词:
卡米尔1 卡米尔1肝细胞癌 肝细胞癌在P53中,P53是P53核武器的扩散索拉费尼布 (Sorafenib) 是一种在 TRIM27 中,乌比奎丁是一种存在的药物.

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