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Updated: Jul 7, 2026

Isolating Nasal Olfactory Stem Cells from Rodents or Humans
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人类诱导的多能干细胞自发分化为对气味敏感的嗅觉感官神经元

Hirokazu Kikuta1, Hidenori Tanaka1, Takashi Ozaki1

  • 1TOYOTA CENTRAL R&D LABS., INC., 41-1, Yokomichi, Nagakute, Aichi, 480-1192, Japan.

Biochemical and biophysical research communications
|May 13, 2024
PubMed
概括

研究人员成功地将诱导多能干细胞 (iPSC) 分化为功能性嗅觉神经元 (OSN). 这些iPSC衍生的OSN表达嗅觉受体并对气味物反应,为再生医学应用铺平了道路.

关键词:
功能性嗅觉反应的功能性嗅觉反应嗅觉是一种嗅觉.嗅觉受体是一种嗅觉受体.嗅觉感官神经元中的嗅觉感官神经元.自发的分化是自发的分化.这些是iPSCs.

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相关概念视频

Olfaction01:25

Olfaction

The sense of smell is achieved through the activities of the olfactory system. It starts when an airborne odorant enters the nasal cavity and reaches olfactory epithelium (OE). The OE is protected by a thin layer of mucus, which also serves the purpose of dissolving more complex compounds into simpler chemical odorants. The size of the OE and the density of sensory neurons varies among species; in humans, the OE is only about 9-10 cm2.
The olfactory receptors are embedded in the cilia of the...
Olfactory Receptors: Location and Structure01:03

Olfactory Receptors: Location and Structure

The process of olfaction, also known as the sense of smell, is a sophisticated chemical response system. The specialized sensory neurons that facilitate this process, known as olfactory receptor neurons, are situated in an upper segment of the nasal cavity, known as the olfactory epithelium. Olfactory sensory neurons are bipolar, with their dendrites extending from the epithelium's apex into the mucus that lines the nasal cavity. Airborne molecules, when inhaled, traverse the olfactory...
Physiology of Smell and Olfactory Pathway01:20

Physiology of Smell and Olfactory Pathway

Humans detect odors with the help of specialized cells located in the upper part of the nasal cavity, called olfactory receptor neurons (ORNs). ORNs possess hair-like structures called cilia, which are receptive to sensations from the inhaled air. When an odorant molecule binds to a specific receptor on the cell of the cilia, it leads to a series of events that ultimately cause the ORN to send electrical signals to the olfactory bulb in the brain through the olfactory nerves.
The olfactory...