25基维生素D度和体力活动对延缓衰老的协同作用
Chang Liu1, Lin Hua2, Zhong Xin1
1Department of Endocrinology, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
Redox biology
|May 13, 2024
概括
较高的维生素D水平和定期的体育活动显著降低了生物衰老. 两者的结合提供了实质性的保护,特别是对于年轻的成年人来说,这表明它们在减缓衰老过程中的重要性.
科学领域:
- 老年学是一门学科.
- 营养生物化学 营养生物化学
- 公共卫生 公共卫生
背景情况:
- 生物衰老,不同于时间的年龄,可以受到生活方式和环境因素的影响.
- 血清25-基维生素D [25(OH) D]和体力活动 (PA) 是可能对衰老产生潜在影响的关键可改变因素.
- 现型年龄 (PhenoAge) 作为生物衰老的生物标志物,反映了整体健康状况.
研究的目的:
- 调查血清25(OH) D度和PA状态与PhenoAge的独立和联合关联.
- 通过优化25OH) D和PA水平来量化表型年龄加速 (PhenoAgeAccel) 的潜在降低.
主要方法:
- 来自NHANES 2007-2010年和2015-2018年数据集的18738名参与者的分析.
- 计算PhenOAgeAccel作为时间表年龄上的回归PhenOAge的余量.
- 权重多变量后勤回归和人口归因分数 (PAF) 分析,以评估关系和潜在的风险降低.
主要成果:
- 高的25~OH) D和足够的PA独立地与降低PhenoAgeAccel风险相关 (ORs <1,p <0.001).
- 在65岁以下的个体中观察到25(OH) D和PA之间的显著的乘法相互作用 (OR = 0.729,p = 0.036).
- 同时高的25(OH) D和足够的PA与PhenoAgeAccel的30.7%下降有关,并将PhenoAge降低了1.291年.
结论:
- 血清25(OH) D水平升高与生物衰老风险降低有关.
- 足够的维生素D和定期体育活动的结合显示出对加快衰老的协同保护作用,特别是在年轻和中年成人中.
- 这些发现强调了适当的维生素D状态和体力活动,可能通过户外活动,在缓解衰老过程中的关键作用.
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