相关实验视频

Updated: Jun 26, 2025

Formation of Dispersible Taohong Siwu Tablets

Formation of Dispersible Taohong Siwu Tablets

Published on: February 3, 2023

用费洛迪平和HPMC为3D打印漂浮片的二元配方的无形固体分散

Gloria Mora-Castaño¹, Mónica Millán-Jiménez¹, Andreas Niederquell²

¹Department of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, Universidad de Sevilla, 41012 Seville, Spain.

International journal of pharmaceutics

|May 13, 2024

概括

这项研究将3D打印 (3DP) 和无形固体分散 (ASD) 结合起来,制造出胃营养浮动片. 这种新的方法实现了药物持续释放超过8小时,推动了制药制造业的发展.

科学领域:

制药技术制药技术制药技术
材料科学材料科学材料科学
药物输送系统药物输送系统

背景情况:

胃药物输送旨在延长药物在胃中的停留时间,以提高治疗效果.
无形固体分散 (ASD) 提高了难以溶解药物的可溶性和生物可用性.
三维打印 (3DP) 为量身定制的药物释放配置文件提供了对平板电脑架构的精确控制.

研究的目的:

开发使用3DP和ASD技术的组合的胃营养漂浮片.
通过热挤出 (HME) 和化沉积建模 (FDM) 在基甲基纤维素 (HPMC) 中研究费洛迪平无形固体分散的形成.
评估3D打印平板电脑的药物释放特性和浮力.

主要方法:

溶解度参数估计和分子动力学模拟以预测药物-聚合物相互作用.
使用HME和使用FDM3D打印的平板电脑制造含有药物的纤维.
纤维和片的物理特征,包括对无形分散和密度的评估.
在体外释放药物的研究和8小时的浮力评估.

主要成果:

在HPMC矩阵内确认了felodipine无形固体分散的成功形成.
具有低充填百分比的3D打印片表现出低密度,确保在整个药物释放过程中保持浮力.
持续的零级药物释放动力学从胃系统获得了超过8小时的时间.
开发的3DP片显示出有效的胃养性质和受控的药物释放.

结论:

3DP和ASD技术的结合是制造先进的胃养浮动平板电脑的一个有前途的方法.
这项研究证明了3DP在创建具有量身定制的释放配置文件的复杂药物输送系统方面的潜力.
开发的配方提供了一种有效的策略,以改善口服的难溶性药物,需要长时间的胃停留时间.

关键词:

通过3D打印打印3D打印.无形固体的分散性固体.装有毒品的细丝带载有毒品的细丝.化沉积物的建模.胃的浮动药片胃的浮动药片零顺序释放释放的时间为零.

更多相关视频

Agarose Fluid Gels Formed by Shear Processing During Gelation for Suspended 3D Bioprinting

Agarose Fluid Gels Formed by Shear Processing During Gelation for Suspended 3D Bioprinting

Published on: May 26, 2023

Using Multilayered Hydrogel Bioink in Three-Dimensional Bioprinting for Homogeneous Cell Distribution

Using Multilayered Hydrogel Bioink in Three-Dimensional Bioprinting for Homogeneous Cell Distribution

Published on: May 2, 2020

相关概念视频

Factors Affecting Dissolution: Polymorphism, Amorphism and Pseudopolymorphism

Factors Affecting Dissolution: Polymorphism, Amorphism and Pseudopolymorphism

Polymorphism refers to the existence of a drug substance in multiple crystalline forms, known as polymorphs. Recently, this term has been expanded to include solvates (forms containing a solvent), amorphous forms (non-crystalline forms), and desolvated solvates (forms from which the solvent has been removed).
Some polymorphic crystals possess lower aqueous solubility than their amorphous counterparts, leading to incomplete absorption. For instance, the oral suspension of Chloramphenicol, which...

Factors Influencing Drug Absorption: Pharmaceutical Parameters

Factors Influencing Drug Absorption: Pharmaceutical Parameters

Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...

Factors Affecting Dissolution: Particle Size and Effective Surface Area

Factors Affecting Dissolution: Particle Size and Effective Surface Area

Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are...