奎尔塞丁封装的聚烯酸-聚烯酸-聚烯酸-罗利电膜作为用于伤口愈合应用的输送系统
Gaetana Paolella1, Antonio Montefusco1, Ivana Caputo1
1Department of Chemistry and Biology "A. Zambelli", University of Salerno, Via Giovanni Paolo II, 132, 84084, Fisciano, SA, Italy.
概括
电聚-ε-拉克 (PCL) 和聚烯 (PVP) 膜装有奎瑞显示了伤口愈合的潜力. 这些膜提供了可控的药物释放,并证明了用于组织修复应用的生物相容性.
科学领域:
- 生物材料科学 生物材料科学
- 聚合物化学 聚合物化学
- 药物输送系统 药物输送系统
背景情况:
- 伤口愈合需要有效的治疗剂.
- 开发用于控制药物释放的先进材料至关重要.
- 奎尔赛丁具有抗氧化和抗炎性质,有利于组织修复.
研究的目的:
- 为了生产和表征电PCL-PVP膜,用于局部输送Quercetin.
- 研究膜的形态学,物理性质和药物释放动力学.
- 评估瑞载荷膜用于伤口愈合的生物活性和生物相容性.
主要方法:
- 聚乙 (PCL) 和聚乙 (PVP) 混合物的电.
- 在各种度 (0.5-15%重量) 中加入奎尔丁.
- 形态分析 (SEM),液体保留,DPPH激素清除活性,奎尔素释放动力学 (菲克定律),以及体外伤口愈合试验 (HaCaT细胞).
主要成果:
- SEM证实了微米纤维具有良好的奎瑞分散.
- 膜表现出受控的液体保留和显著的激素清理活动.
- 奎尔素释放显示了最初的爆发,随后持续释放超过50小时.
- 实验室试验证明了生物相容性和有效性,促进状细胞迁移用于伤口愈合.
结论:
- 电PCL-PVP膜适用于受控的局部氏素输送.
- 这些膜显示出作为创伤愈合应用的生物材料的前景.
- 这项研究证实了微调药物释放特征以获得治疗益处的潜力.
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