非典型脑膜瘤与其他世卫组织2级脑膜瘤相比:组织学特征和预后
Abdulrazag Ajlan1, Saif Almeshari1, Sarah Basindwah1
1From the Division of Neurosurgery (Ajlan, Basindwah, Alqurashi), Department of Surgery, College of Medicine, King Saud University, from the College of Medicine (Almeshari, Aljohani, Alharbi, Aldhowaihy), King Saud University, and from the Department of Pathology (Alkhaldi), College of Medicine, King Saud University, Riyadh, Kingdom of Saudi Arabia.
Neurosciences (Riyadh, Saudi Arabia)
|May 13, 2024
概括
这项研究发现,非典型脑膜瘤和其他世卫组织2级脑膜瘤的复发率相似. 特定的病理特征并不能显著预测这些瘤的复发风险.
科学领域:
- 神经外科 神经外科
- 病理学 病理学 病理学
- 在瘤学瘤学.
背景情况:
- 脑膜瘤是来自脑膜的瘤.
- 世卫组织2级脑膜瘤,包括非典型脑膜瘤 (AM),与1级相比,其复发潜力增加.
- 在2级脑膜瘤中区分预后因素仍然不清楚.
研究的目的:
- 调查非典型脑膜瘤与其他世卫组织2级脑膜瘤之间的特定非典型特征和复发之间的关联.
- 确定某些病理特征是否预示着更具侵略性的行为或更高的复发风险.
主要方法:
- 在2008年至2020年间对74名世卫组织2级脑膜瘤患者进行了回顾性分析.
- 评估复发率,重新操作率和再接收率.
- 统计分析以将病理特征与复发相关联.
主要成果:
- 异型脑膜瘤 (AM) 在81%的病例中存在;管状或透明细胞脑膜瘤在19%的病例中存在.
- 增加的核-细胞质比率和细胞性在AM中更为普遍.
- 整体复发率为16.2%,在特定的病理特征或脑膜瘤亚型和复发之间没有发现显著的联系.
结论:
- 世卫组织2级脑膜瘤,包括非典型和其他亚型,显示出可比的预后和复发率.
- 2级脑膜瘤中的非典型特征并不显著表明更具侵略性或复发风险增加.
相关概念视频
Viral Meningitis
191
Viral meningitis is the most common form of meningitis and is often referred to as aseptic meningitis to indicate the absence of bacterial involvement. It is generally milder than bacterial meningitis, with symptoms including fever, headache, stiff neck, drowsiness, nausea, photophobia, and vomiting. Rarely, more severe manifestations or death may occur. Common causative agents include enteroviruses, particularly coxsackie A and B viruses and echoviruses, all members of the Enterovirus genus...
191
Bacterial Meningitis I: Introduction
12
Bacterial meningitis is a severe, life-threatening inflammation of the meninges, particularly the pia mater and arachnoid mater, affecting the subarachnoid space, ventricles, and cerebrospinal fluid (CSF). If untreated, it can lead to significant neurological complications or death.Causative AgentsCommon pathogens vary with age and immune status. In adults, major organisms include Streptococcus pneumoniae, Neisseria meningitidis, and Haemophilus influenzae. Streptococcus agalactiae (group B...
12
Bacterial Meningitis II: Pathophysiology
16
Bacterial meningitis typically begins when pathogens such as Neisseria meningitidis and Streptococcus pneumoniae colonize the nasopharynx and invade the bloodstream. This process is facilitated by bacterial virulence factors, such as polysaccharide capsules, which resist phagocytosis and complement-mediated killing. Less commonly, bacteria reach the central nervous system via contiguous spread from infections like otitis media or sinusitis, through congenital or acquired dural defects, or...
16


