来自Croton Sublyratus的A-H克罗托诺酸,拉巴丹型的迪特尔佩诺酸具有抗炎活性
Jing-Jing Qi1,2, Ying Li3, Rui-Yao Fu1,2
1State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai, 201203, People's Republic of China.
Chemistry & biodiversity
|May 13, 2024
概括
从泰国药用植物Croton sublyratus中分离出了八种新的拉巴丹类型的二类植物. 一种化合物通过抑制细胞中氧化的产生,显示出抗炎活性.
科学领域:
- 自然产品化学 自然产品化学
- 植物化学 植物化学
- 药用植物研究 药用植物研究
背景情况:
- 克罗顿 (Croton sublyratus) 是泰国传统的药用植物.
- 它用于治疗虫感染和皮肤病症.
研究的目的:
- 从Croton sublyratus的空气部位中分离和描述新的四面体.
- 为了评估分离的化合物的抗炎潜力.
主要方法:
- 使用色谱技术分离化合物.
- 通过光谱数据分析 (NMR,MS),电子圆二元化 (ECD) 计算和单晶X射线衍射来阐明结构.
- 在体外抗炎测定使用脂聚糖诱导的RAW 264.7细胞来测量氧化 (NO) 生产.
主要成果:
- 分离了八种新的拉巴丹类型的二类,克罗托诺类A-H (1-8),以及一种已知的类似物 (9).
- 化合物6和7是罕见的14,15-dinor-labdane二烯化合物.
- 复合物8拥有一个罕见的14,15,17-trinor-labdane骨架.
- 化合物9通过抑制NO生产,显示出中度的抗炎活性.
结论:
- 这项研究成功地从Croton sublyratus.中发现了新型的二类动物.
- 克罗顿类动物 (Croton sublyratus) 是结构独特的拉巴丹二类动物的来源.
- 化合物9显示出作为抗炎剂的潜力.
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