在马塞特高患者中注射肉毒素A后骨肌肉的变化:一项随机的三盲试验
Bryanne B de Souza Nobre1, Luciana de Oliveira Resende Machado1, Rodrigo Lorenzi Poluha2
1Department of Dentistry, Ingá University Center, Uningá, Paraná, Brazil.
Aesthetic plastic surgery
|May 13, 2024
概括
毒素A (BoNT-A) 注射用于马塞特缩可以改变肌肉的厚度和活动. 多次BoNT-A治疗可能会导致肌的结构和功能变化更为明显.
科学领域:
- 神经学 神经学
- 整形外科 整形外科 整形外科
- 审美学 在审美学方面
背景情况:
- 马塞特肌缩 (Masseter hypertrophy) 是一种以马塞特肌肉扩大为特征的疾病.
- 毒素A (BoNT-A) 是一种用于化品和治疗目的的神经毒素.
- 在患有马塞特缩症的患者中,BoNT-A对肌的影响尚未完全理解.
研究的目的:
- 为了研究BoNT-A治疗masseter增大症对相邻的肌肌肉的影响.
- 评估时肌肉厚度,电肌图 (EMG) 活动和疼痛的变化.
- 为了评估单次与多次BoNT-A治疗会话的影响.
主要方法:
- 一个随机的,三重失明的临床试验,涉及26名女性参与者,患有巨增大.
- 参与者在按摩器肌肉中接受了75U的abobotulinumtoxinA (BoNT-A).
- 1,3,6个月后的随访评估包括超声波测定肌厚度,EMG活性,主观疼痛和masseter突出严重程度.
主要成果:
- 与盐水组相比,接受多次BoNT-A注射 (M-BoNT-A) 的组在6个月内显示出明显更高的肌厚度和EMG活性.
- 在6个月的随访期间,M-BoNT-A组也报告了疼痛区域的更高患病率.
- 在6个月后的群体之间没有观察到masseter突出严重程度的显著差异.
结论:
- 对于masseter缩的BoNT-A治疗诱导肌的结构和功能变化.
- 多次BoNT-A治疗似乎会放大肌肌中的这些变化.
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