早期生活压力与更大的负面情绪和酒精使用障碍中周围炎症有关
Dylan E Kirsch1, Erica N Grodin1,2, Steven J Nieto1
1Department of Psychology, University of California, Los Angeles, 1285 Franz Hall, Box 951563, Los Angeles, CA, 90095-1563, USA.
概括
早期生活压力 (ELS) 通过增加负面情绪和炎症,显著影响酒精使用障碍 (AUD). 高ELS暴露与AUD患者的独特神经临床和炎症特征有关.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 免疫学 免疫学 免疫学
背景情况:
- 早期生活压力 (ELS) 是精神疾病的已知危险因素,包括酒精使用障碍 (AUD).
- 同样的精神病诊断的个体可能会根据ELS病史表现出不同的临床和生物特征.
- 这种假设在情绪障碍方面得到了很好的支持,但在AUD方面仍然基本未被探索.
研究的目的:
- 研究ELS对AUD神经临床现象学的影响.
- 在AUD中检查ELS和外周炎症标志物之间的关联.
- 确定累积ELS是否预测特定的AUD相关的神经临床领域和炎症概况.
主要方法:
- 寻求治疗的AUD成年人 (N=163) 用不良童年经历 (ACE) 调查问卷对ELS进行了评估.
- 参与者被分为没有ELS (ACE=0),中度ELS (ACE=1-3) 和高ELS (ACE≥4) 组.
- 使用成神经临床评估领域 (激励突出,负面情绪) 评估神经临床现象学. 通过C反应蛋白 (CRP) 在子集 (N=98) 中测量了周围炎症.
主要成果:
- 更大的累积ELS预测了更高的负面情绪和更高的CRP水平,但不是激励突出.
- 与没有ELS和中度ELS组相比,高ELS组显示出明显更大的负面情绪.
- 在高ELS组中观察到较高的CRP水平,与没有/中等ELS组组合相比.
结论:
- 高ELS暴露与AUD中明显的神经临床表现有关,其特征是增加负面情绪.
- 通过CRP表示的外周炎症升高与AUD患者更高的ELS暴露有关.
- 研究结果表明,ELS显著塑造了AUD的表型和生物基础,突出了潜在的干预目标.
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