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Updated: May 11, 2026

HLA-Ig Based Artificial Antigen Presenting Cells for Efficient ex vivo Expansion of Human CTL
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高分辨率的非洲HLA资源揭示了疫苗反应背后的HLA-DRB1表达效应

Alexander J Mentzer1,2, Alexander T Dilthey3,4,5, Martin Pollard6

  • 1Centre for Human Genetics, University of Oxford, Oxford, UK. alexander.mentzer@ndm.ox.ac.uk.

Nature medicine
|May 13, 2024
PubMed
概括

人类遗传变异,特别是人类白细胞抗原 (HLA) 基因,影响婴儿疫苗抗体反应. 了解不同人群中的这些遗传因素是提高疫苗有效性的关键.

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Diversity of Antigen Receptors01:28

Diversity of Antigen Receptors

Antigen receptors are essential components of the immune system crucial in defending the body against foreign invaders. These receptors are present on the surface of B and T cells, enabling them to recognize antigens and mount an appropriate immune response.
Before encountering any antigen, lymphocytes express these receptors. On B cells, the antigen receptor is a membrane-bound antibody molecule called BCR; on T cells, it is a T cell receptor or TCR. B and T cell receptors are composed of two...