新辅助免疫化学疗法与肺平细胞癌手术之间的治疗间隔的影响
Chen Gu1,2, Xiao Teng1, Xuqi Sun1
1Thoracic Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, 79 Qingchun Road, Shangcheng District, Hangzhou, 310000, China.
BMC cancer
|May 13, 2024
概括
新辅助免疫化学疗法和手术之间的较短间隔可以改善肺平细胞癌患者的无疾病生存率 (DFS). 避免长时间的治疗延迟以优化结果.
科学领域:
- 在瘤学瘤学.
- 胸部外科手术 胸部外科手术
- 免疫治疗是一种免疫疗法.
背景情况:
- 在肺状细胞癌 (LSCC) 中新辅助免疫化疗后进行手术的最佳时间缺乏明确的指导方针.
- 关于新辅助免疫化学疗法和LSCC手术干预之间的间隔影响的数据有限.
研究的目的:
- 研究新辅助免疫化学疗法和手术之间的时间间隔对LSCC患者的生存结果的影响.
- 为了确定更短或更长的间隔是否会影响无病生存率 (DFS) 和整体生存率 (OS).
主要方法:
- 对接受新辅助免疫化疗的LSCC患者的回顾性分析 (2019年1月至2022年10月).
- 患者被分为两组:间隔≤33天和>33天.
- 主要终点:DFS和OS.主要终点:DFS和OS.主要终点:DFS和OS. 二级终点:目标反应率 (ORR),主要病理反应 (MPR),病理完全缓解 (pCR).
主要成果:
- 较短的间隔 (≤33天) 与较长的间隔 (>33天) 相比,与显著优异的DFS相关 (p=0.0015).
- 中位数的DFS为952天 ≤33天,而590天>33天.
- 两组之间在OS,ORR,MPR或pCR方面没有显著差异.
结论:
- 新辅助免疫化学疗法和手术之间的较短治疗间隔与LSCC中改善的DFS相关.
- 间隔似乎不会影响OS,病理反应或手术安全性.
- 建议患者不要在新辅助疗法和手术切除之间延长时间.
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