高剂量的纳洛配方并不像我们想象的那样重要
Paige M Lemen1,2, Daniel P Garrett3, Erin Thompson4
1Tennessee Harm Reduction, 1989 Madison Avenue, 7, Memphis, TN, 38104, USA. plemen1@uthsc.edu.
Harm reduction journal
|May 14, 2024
概括
对于芬太尼过量服用,通常足够服用两剂纳洛 (一种阿片类药物过量逆转药物) 的标准剂量. 由于成本和风险,不建议使用高剂量配方.
科学领域:
- 紧急医疗 紧急医疗
- 药理学 药理学是指药理学的学科.
- 公共卫生 公共卫生
背景情况:
- 纳洛是一种FDA批准的阿片类药物抗剂,对于逆转阿片类药物过量服用至关重要.
- 通过肌内 (IM),静脉 (IV) 和鼻内喷雾 (IN) 途径向公众提供.
- 芬太尼的功效需要了解最佳的纳洛剂量策略.
研究的目的:
- 为了评估标准剂量纳洛与高剂量配方对芬太尼过量逆转的有效性.
- 将吸毒者的观点纳入实践分析.
- 为纳洛的管理提供基于证据的建议.
主要方法:
- 文学评论比较标准和高剂量纳洛在芬太尼过量服用中的疗效.
- 包括从有毒品使用实体经验的个体获得的定性数据.
- 对剂量充足性的分析,急性戒断风险和重复过量可能的分析.
主要成果:
- 两个标准的IM或IN纳洛剂量有效地逆转大多数芬太尼过量服用.
- 过量服用卡芬坦尼尔可能需要三剂或更多剂量才能逆转.
- 增加的纳洛剂量 (≥2) 携带着急性戒断和潜在的过量复发的风险.
结论:
- 向旁观者分发多个标准剂量的纳洛套件,并教育关于两剂费坦尼尔过量剂量的充足性.
- 给纳洛,直到复苏,救援呼吸,并打电话给急救服务,如果两个剂量后没有反应.
- 标准剂量纳洛因成本,安全性和证据而优先于高剂量配方.
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