比利时的抗逆转录病毒治疗不遵守和不持续:使用药房数据库的现实世界评估,2018-2021年
Dieudonné Ilboudo1,2, Patricia Mbouche1, Agnès Sommet3
1Centre de recherche Epidémiologie, Biostatistique et Recherche Clinique, Ecole de santé publique, Université libre de Bruxelles (U.L.B.), Bruxelles, Belgium.
Pharmacoepidemiology and drug safety
|May 14, 2024
概括
比利时的艾滋病毒治疗坚持情况有所改善,但仍然令人担忧. 不遵守和不坚持率下降,但妇女和布鲁塞尔居民面临更高的风险,突出了针对性干预的必要性.
科学领域:
- 公共卫生 公共卫生
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
背景情况:
- 抗逆转录病毒疗法 (ART) 对于治疗艾滋病毒感染至关重要.
- 坚持ART是治疗有效性和预防耐药性的关键.
- 了解现实世界的坚持模式对于优化患者结果至关重要.
研究的目的:
- 评估现实世界对ART的不坚持和不坚持率.
- 评估比利时以前未接受过治疗的成年艾滋病毒患者中的这些发病率.
- 在12个月的随访期内分析趋势.
主要方法:
- 纵向药房声明的回顾性分析 (Pharmanet数据库,2018-2021年).
- 不遵守定义为覆盖日数的比例<80%.
- 非持续性被定义为治疗中的第一个90天间隙.
主要成果:
- 不遵守的比例从35.6% (2018年) 降至18.7% (2021年).
- 不持久性从15.9% (2018年) 减少到6.8% (2021年).
- 在妇女,布鲁塞尔居民和那些服用多片药片 (MTR) 的人群中观察到更高的不遵守和不坚持.
结论:
- ART的坚持性有所改善,但仍然很高.
- 基于性别和地区,依从性存在显著差异.
- 建议制定针对布鲁塞尔妇女的战略,并从MTRs过渡.
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