[自身免疫自主性节病变和急性自主性感官神经病变]
1Department of Neurology, Faculty of Medicine, Academic Research Division, University of Toyama.
Brain and nerve = Shinkei kenkyu no shinpo
|May 14, 2024
概括
自身免疫性自主性淋巴结膜病变 (AAG) 和急性自主性感官神经病变 (AASN) 是不同的免疫媒介神经病变. 尽管有不同的自身抗体,但共同的大脑和内分泌症状表明潜在的共同潜在的病理生理学.
科学领域:
- 神经学 神经学
- 免疫学 免疫学 免疫学
- 病理生理学 病理生理学
背景情况:
- 自身免疫性自主性淋巴结膜病变 (AAG) 和急性自主性感官神经病变 (AASN) 是免疫媒介的神经病变,影响神经.
- AAG的发病过程涉及针对尼古丁性腺性乙胆受体 (gAChR) 的自身抗体,这些抗体在AASN中不存在.
- 临床和实验室发现目前将AAG和AASN分开为不同的疾病概念.
研究的目的:
- 探索AAG和AASN之间潜在的共享病理生理学.
- 在这两种情况中,研究超自主性大脑和内分泌症状的意义.
主要方法:
- 对AAG和AASN患者的临床症状和实验室发现的审查.
- 分析自身抗体概况,特别是gAChR抗体.
- 对神经,精神和内分泌表现的比较评估.
主要成果:
- 对gAChR的自身抗体是AAG的特征,但不是AASN.
- 无论是AAG还是AASN都呈现出额外自主性脑部症状,包括精神病和人格变化.
- 在患有AAG和AASN的患者中观察到内分泌疾病.
结论:
- 尽管有不同的免疫学标志物,但类似的超自主大脑和内分泌症状的发生表明AAG和AASN之间有共同的病理生理基础.
- 需要进一步的研究来阐明这些免疫介导的神经病变背后的共同机制.
相关概念视频
Disorders of the Autonomic Nervous System
626
The autonomic nervous system (ANS) is an intricate network of nerves that controls functions such as the regulation of heart rate, digestion, and blood pressure regulation. When this system malfunctions, it can lead to various disorders that affect multiple bodily functions. One common feature of many autonomic disorders is the involvement of smooth blood vessels, which play a crucial role in regulating blood flow throughout the body.
Raynaud's disease, also known as Raynaud's...
Raynaud's disease, also known as Raynaud's...
626
Drugs Acting on Autonomic Ganglia: Blockers
1.0K
Ganglionic blockers inhibit autonomic activity by blocking nicotinic receptors in the autonomic ganglia, suppressing impulse transmission. These blockers lack selectivity between sympathetic and parasympathetic ganglia and are ineffective as neuromuscular junction antagonists. They can be categorized into two groups:
1.0K
Peripheral Nervous System: Ganglia and Nerves
1.8K
The Peripheral Nervous System (PNS) is a crucial component of the body's neural network, extending beyond the central nervous system (CNS) to bridge the gap between the CNS and the external environment. It encompasses nerves, ganglia, and sensory receptors.
Nerves
The nerve is a bundle of axons that serves as the communication highway in the PNS. Each nerve is ensheathed in a protective layer of connective tissue called the epineurium. This outermost layer safeguards the nerve and supports the...
Nerves
The nerve is a bundle of axons that serves as the communication highway in the PNS. Each nerve is ensheathed in a protective layer of connective tissue called the epineurium. This outermost layer safeguards the nerve and supports the...
1.8K
Autonomic Nervous System: Overview
4.1K
The human nervous system is divided into two main parts: the central nervous system (CNS) and the peripheral nervous system (PNS). The CNS is composed of the brain and spinal cord, while the PNS contains nerve cells, clusters of nerve cells, and the sensory receptors that are outside the CNS. The PNS has two types of nerve cells: sensory (afferent) and motor (efferent). Sensory cells send signals to the CNS from receptors, and motor cells carry signals from the CNS to organs, muscles, and...
4.1K
Myasthenia Gravis: Overview and Treatment
1.4K
Myasthenia gravis is a neuromuscular transmission disorder characterized by weakness and increased fatigability of skeletal muscles. It is an autoimmune disease affecting approximately one in 2000 people, where antibodies against the α1 subunit of nicotinic acetylcholine receptors are produced.
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which...
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which...
1.4K
Autonomic Nervous System
8.7K
The autonomic nervous system (ANS) is a critical component of the peripheral nervous system, primarily responsible for regulating involuntary bodily functions and maintaining homeostasis. It functions in tandem with the central nervous system (CNS) to seamlessly coordinate various physiological processes without the need for conscious control.
The ANS comprises two main divisions: the sympathetic and parasympathetic divisions. These divisions function antagonistically to maintain a dynamic...
The ANS comprises two main divisions: the sympathetic and parasympathetic divisions. These divisions function antagonistically to maintain a dynamic...
8.7K


