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相关概念视频

Skin Diseases and Disorders01:23

Skin Diseases and Disorders

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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
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Papillary Dermis01:11

Papillary Dermis

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Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen...
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Disorders of the Skeletal Muscle01:28

Disorders of the Skeletal Muscle

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The clinical conditions affecting the skeletal muscle tissue are broadly categorized as musculoskeletal and neuromuscular disorders.
Musculoskeletal disorders
Musculoskeletal disorders involve injuries and conditions affecting the skeletal muscles and associated connective tissues. These disorders can arise from acute biomechanical stresses or chronic overuse and can occur across different age groups. Common injuries include sprains, fractures, and muscular strains, often resulting from...
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Myasthenia Gravis: Overview and Treatment01:20

Myasthenia Gravis: Overview and Treatment

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Myasthenia gravis is a neuromuscular transmission disorder characterized by weakness and increased fatigability of skeletal muscles. It is an autoimmune disease affecting approximately one in 2000 people, where antibodies against the α1 subunit of nicotinic acetylcholine receptors are produced.
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which...
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Reticular Dermis01:15

Reticular Dermis

2.5K
The papillary and reticular dermis are the two layers of the dermis. They are made of connective tissue with fibers of collagen extending from one to the other, making the border between the two somewhat indistinct. The dermal papillae extending into the epidermis belong to the papillary layer, whereas the dense collagen fiber bundles below belong to the reticular layer.
Reticular Layer
Underlying the papillary layer is the much thicker reticular layer, composed of dense, irregular connective...
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Tissue Membranes01:27

Tissue Membranes

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A tissue membrane is a thin layer of cells that covers the outside of the body, the organs, internal passageways that lead to the exterior of the body, and the lining of the moveable joint cavities. There are two basic types of tissue membranes— connective tissue and epithelial membranes.
Connective Tissue Membranes
The connective tissue membrane is formed solely from connective tissue. These membranes encapsulate organs, such as the kidneys, and line our movable joints. A synovial...
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相关实验视频

Updated: Jun 26, 2025

Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus
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Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus

Published on: May 16, 2025

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[皮肤病] 皮肤病

Kazuma Sugie1

  • 1Department of Neurology, Nara Medical University School of Medicine.

Brain and nerve = Shinkei kenkyu no shinpo
|May 14, 2024
PubMed
概括
此摘要是机器生成的。

皮质肌炎 (DM) 是一种自身免疫性疾病,其特征是皮肤皮疹和肌肉疲弱. 目前的治疗包括皮质类固醇和免疫抑制剂,但耐火病例需要新的治疗策略.

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Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
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Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis

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Imaging CD4 T Cell Interstitial Migration in the Inflamed Dermis
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相关实验视频

Last Updated: Jun 26, 2025

Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus
05:38

Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus

Published on: May 16, 2025

58
Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
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Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis

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Imaging CD4 T Cell Interstitial Migration in the Inflamed Dermis
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Imaging CD4 T Cell Interstitial Migration in the Inflamed Dermis

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科学领域:

  • 类风湿病学 类风湿病学
  • 免疫学 免疫学 免疫学
  • 神经学 神经学

背景情况:

  • 皮肤肌炎 (DM) 是一种由特定的皮肤皮疹,肌肉病理和症状定义的特异性炎症性肌肉病.
  • 五种肌炎特异性自身抗体与DM的不同临床表现有关.
  • 病理学发现将DM归类为一种骨肌肉类型I干扰症.

研究的目的:

  • 审查诊断标准,自身抗体相关性和皮肤肌肉炎的病理基础.
  • 讨论DM当前的治疗策略,包括一线和二线疗法.
  • 突出管理耐火性DM病例的挑战以及需要新型治疗方法的需求.

主要方法:

  • 审查关于皮肤肌炎诊断,自身抗体和病理学的现有文献.
  • 对DM当前治疗指南和临床结果的分析.
  • 识别对抗治疗的DM治疗选择中的差距.

主要成果:

  • 诊断DM依赖于特征性皮肤表现,肌肉病理和症状.
  • 已确定的自身抗体提供了明确的临床相关性.
  • DM的特征是骨肌肉中的I型干扰症.
  • 皮质类固醇是第一线的,免疫抑制剂和IVIg是第二线的选择.
  • 很大一部分患者表现出对当前治疗方法的耐药性.

结论:

  • 有效的DM管理需要对临床和病理因素进行全面评估.
  • 虽然已确立的治疗方法存在,但耐火病例构成了重大的临床挑战.
  • 对于耐火性皮肤肌肉炎,进一步研究和开发创新的治疗方式至关重要.