导航神经系统疾病:利用自然化合物的力量,实现创新的治疗突破
Rapuru Rushendran1, Rukaiah Fatma Begum1, Ankul Singh S1
1Department of Pharmacology, SRM College of Pharmacy, SRM Institute of Science and Technology, Kattankulathur- 603 203, Tamil Nadu, India.
EXCLI journal
|May 14, 2024
概括
来自植物和海洋的天然化合物显示出对治疗神经系统疾病如阿尔茨海默氏症和帕金森症的希望. 进一步的研究对于开发安全有效的神经保护疗法至关重要.
科学领域:
- 神经科学和药理学 神经科学和药理学
- 自然产品化学 自然产品化学
- 药物发现 药物发现 药物发现
背景情况:
- 随着全球神经系统疾病患病率的增加,需要新的治疗策略.
- 自然资源 (植物,海洋,微生物) 是潜在的药物发现化合物的丰富储库.
- 关于阿尔茨海默病,帕金森病和中风的现有评论强调了神经系统疾病的复杂性和天然物质的安全性.
研究的目的:
- 探索海洋衍生和植物性物质的神经保护特征和应用.
- 讨论这些天然化合物的神经治疗效应背后的分子通路.
- 审查特定天然化合物的临床使用,如布里奥斯塔丁-1,富可伊丹,伊卡林,沙尔维亚诺酸,黄素和白醇.
主要方法:
- 文献审查和对自然化合物和神经系统疾病现有研究的分析.
- 检查与神经保护剂有关的分子机制和临床数据.
- 讨论在喘和阿尔茨海默病等疾病中的潜在应用.
主要成果:
- 自然物质,包括海洋衍生和植物化合物,表现出显著的神经保护潜力.
- 库尔库明和白醇等特定化合物通过各种分子通路显示出有希望的结果.
- 正在探索临床应用,尽管仍然存在挑战和复杂性.
结论:
- 天然化合物为治疗神经疾病提供了一个有前途的途径,对阿尔茨海默病等疾病有潜在的益处.
- 严格的科学研究,跨学科的合作和道德考虑对于未来的发展至关重要.
- 建议对尚未探索的化合物进行进一步的研究,进行质量控制和结构良好的临床试验.
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